Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines
about
Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesisCompleting the structural family portrait of the human EphB tyrosine kinase domainsDiscovery of a Novel Chemotype of Tyrosine Kinase Inhibitors by Fragment-Based Docking and Molecular DynamicsHydrogen bonding penalty upon ligand bindingModeling error in experimental assays using the bootstrap principle: understanding discrepancies between assays using different dispensing technologies.Dispensing processes impact apparent biological activity as determined by computational and statistical analyses.Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors.The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesisEph receptors and ephrins in cancer: bidirectional signalling and beyond.Targeting the DFG-in kinase conformation: a new trend emerging from a patent analysis.Targeting Eph receptors with peptides and small molecules: progress and challenges.Therapeutic targeting of EPH receptors and their ligands.A novel benzodioxole-containing inhibitor of Toxoplasma gondii growth alters the parasite cell cycle.The EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target.Fluorine-18 radiolabeling and radiopharmacological characterization of a benzodioxolylpyrimidine-based radiotracer targeting the receptor tyrosine kinase EphB4.Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles.Kinase selectivity potential for inhibitors targeting the ATP binding site: a network analysis.Preparation of a novel radiotracer targeting the EphB4 receptor via radiofluorination using spiro azetidinium salts as precursor.EphB4: A promising target for upper aerodigestive malignancies.N-(2,4)-dinitrophenyl-L-arginine Interacts with EphB4 and Functions as an EphB4 Kinase Modulator.
P2860
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P2860
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@ast
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@en
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@nl
type
label
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@ast
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@en
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@nl
prefLabel
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@ast
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@en
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@nl
P2093
P1476
Inhibitors of the tyrosine kin ...... of 2,4-bis-anilinopyrimidines
@en
P2093
Andrew Mortlock
Catherine Bardelle
Darren Cross
Emma J Williams
Eun Jung Ko
Jason G Kettle
Nicola J Roberts
Peter Robins
Sara Davenport
P304
P356
10.1016/J.BMCL.2008.04.015
P407
P50
P577
2008-04-10T00:00:00Z