Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk - Wikidata - wikimedia - TriplyDB

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

http://www.wikidata.org/entity/Q27650747

about

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6 Dickkopfs and Wnt/β-catenin signalling in liver cancer Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo Wnt gene expression in human trabecular meshwork cells.Engineering potent long-acting variants of the Wnt inhibitor DKK2 To beta or not to beta: canonical beta-catenin signaling pathway and ovarian development Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.Solvated protein-DNA docking using HADDOCK.Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands Activation of type II cells into regenerative stem cell antigen-1(+) cells during alveolar repair.Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.The first propeller domain of LRP6 regulates sensitivity to DKK1.On target? Strategies and progress in the development of therapies for colorectal cancer targeted against WNT signalling.Investigational anabolic therapies for osteoporosis.Hepatitis C virus core protein activates Wnt/β-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line.MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.Discovery of Klotho peptide antagonists against Wnt3 and Wnt3a target proteins using combination of protein engineering, protein-protein docking, peptide docking and molecular dynamics simulations.Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf.Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.Ancient cytokines, the role of astakines as hematopoietic growth factors.The structural basis of DKK-mediated inhibition of Wnt/LRP signaling Common structural traits for cystine knot domain of the TGFβ superfamily of proteins and three-fingered ectodomain of their cellular receptors.Essential role of Dkk3 for head formation by inhibiting Wnt/β-catenin and Nodal/Vg1 signaling pathways in the basal chordate amphioxus.Vaccination with DKK1-derived peptides promotes bone formation and bone mass in an aged mouse osteoporosis model.

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P2860

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

http://www.wikidata.org/entity/Q27650747

description

2008 nî lūn-bûn

@nan

2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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type

label

Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk

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Journal of Biological Chemistry

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Structural insight into the mechanisms of Wnt signaling antagonism by Dkk

@en

P2093

Dianqing Wu

http://www.w3.org/2001/XMLSchema#string

Jufang Shan

http://www.w3.org/2001/XMLSchema#string

Ke Wang

http://www.w3.org/2001/XMLSchema#string

Lijun Chen

http://www.w3.org/2001/XMLSchema#string

Xiaofeng Li

http://www.w3.org/2001/XMLSchema#string

Youming Shao

http://www.w3.org/2001/XMLSchema#string

P2860

Functional and structural diversity of the human Dickkopf gene family

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled

Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.

Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway

Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair

The solution structure of acyl carrier protein from Mycobacterium tuberculosis

Structure of the LDL receptor extracellular domain at endosomal pH

Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface

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23364-23370

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10.1074/JBC.M802375200

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34

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283

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2517007

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