Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
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Mechanism for controlling the monomer-dimer conversion of SARS coronavirus main proteaseCharacterization of Bafinivirus main protease autoprocessing activities.Mutation of Glu-166 blocks the substrate-induced dimerization of SARS coronavirus main protease.Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method.Profiling of substrate specificities of 3C-like proteases from group 1, 2a, 2b, and 3 coronaviruses.Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistanceCrystallization and preliminary crystallographic study of Porcine epidemic diarrhea virus main protease in complex with an inhibitorExpression, crystallization and preliminary crystallographic study of the functional mutant (N60K) of nonstructural protein 9 from Human coronavirus HKU1.Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: homology modelling and molecular dynamic studies.Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity.Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activityPurification, crystallization and preliminary X-ray analysis of nonstructural protein 2 (nsp2) from avian infectious bronchitis virus.Potential Broad Spectrum Inhibitors of the Coronavirus 3CLpro: A Virtual Screening and Structure-Based Drug Design Study.Porcine Epidemic Diarrhea Virus 3C-Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO.Crystal Structure of Feline Infectious Peritonitis Virus Main Protease in Complex with Synergetic Dual Inhibitors.Conformational Flexibility of a Short Loop near the Active Site of the SARS-3CLpro is Essential to Maintain Catalytic Activity.Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like proteaseExpression, crystallization and preliminary crystallographic study of human coronavirus HKU1 nonstructural protein 9.Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activityTherapies for coronaviruses. Part 2: Inhibitors of intracellular life cycle.Functional and genetic studies of the substrate specificity of coronavirus infectious bronchitis virus 3C-like proteinase.Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China.
P2860
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P2860
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@ast
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@en
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@en-gb
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@nl
type
label
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@ast
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@en
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@en-gb
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@nl
prefLabel
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@ast
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@en
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@en-gb
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@nl
P2093
P2860
P50
P356
P1433
P1476
Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1
@en
P2093
P2860
P304
P356
10.1128/JVI.00298-08
P577
2008-09-01T00:00:00Z