Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme
about
Shared traits on the reaction coordinates of ribonuclease and an RNA enzymeIdentification of an Imino Group Indispensable for Cleavage by a Small RibozymePrevalence of syn nucleobases in the active sites of functional RNAsExploring ribozyme conformational changes with X-ray crystallography.Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental data.Metrics for comparison of crystallographic maps.Catalytic importance of a protonated adenosine in the hairpin ribozyme active siteMolecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme.Theoretical studies of RNA catalysis: hybrid QM/MM methods and their comparison with MD and QM.Nucleases: diversity of structure, function and mechanism.Thermodynamics and kinetics of RNA tertiary structure formation in the junctionless hairpin ribozyme.QM/MM studies of hairpin ribozyme self-cleavage suggest the feasibility of multiple competing reaction mechanisms.Extensive molecular dynamics simulations showing that canonical G8 and protonated A38H+ forms are most consistent with crystal structures of hairpin ribozyme.General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation.Design of hairpin ribozyme variants with improved activity for poorly processed substrates.A novel strategy of chemical modification for rate enhancement of 10-23 DNAzyme: a combination of A9 position and 8-aza-7-deaza-2'-deoxyadenosine analogs.
P2860
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P2860
Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@ast
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@en
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@nl
type
label
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@ast
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@en
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@nl
prefLabel
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@ast
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@en
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@nl
P2093
P2860
P356
P1433
P1476
Structural effects of nucleoba ...... Ade38 in the hairpin ribozyme
@en
P2093
Celeste MacElrevey
Jason D Salter
Jolanta Krucinska
Joseph E Wedekind
P2860
P304
P356
10.1261/RNA.1055308
P407
P577
2008-08-01T00:00:00Z