Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines
about
Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesisDevelopment of o -Chlorophenyl Substituted Pyrimidines as Exceptionally Potent Aurora Kinase InhibitorsCompleting the structural family portrait of the human EphB tyrosine kinase domainsDispensing processes impact apparent biological activity as determined by computational and statistical analyses.The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesisBiomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes.Eph receptors and ephrins in cancer: bidirectional signalling and beyond.Eph receptors and ephrins as targets for cancer therapy.Targeting the DFG-in kinase conformation: a new trend emerging from a patent analysis.A novel benzodioxole-containing inhibitor of Toxoplasma gondii growth alters the parasite cell cycle.Novel EPHB4 Receptor Tyrosine Kinase Mutations and Kinomic Pathway Analysis in Lung CancerThe EphB4 receptor tyrosine kinase promotes lung cancer growth: a potential novel therapeutic target.Fluorine-18 radiolabeling and radiopharmacological characterization of a benzodioxolylpyrimidine-based radiotracer targeting the receptor tyrosine kinase EphB4.Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles.An efficient bioorthogonal strategy using CuAAC click chemistry for radiofluorinations of SNEW peptides and the role of copper depletion.Preparation of a novel radiotracer targeting the EphB4 receptor via radiofluorination using spiro azetidinium salts as precursor.EphB4: A promising target for upper aerodigestive malignancies.N-(2,4)-dinitrophenyl-L-arginine Interacts with EphB4 and Functions as an EphB4 Kinase Modulator.
P2860
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P2860
Inhibitors of the tyrosine kinase EphB4. Part 2: structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@ast
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@en
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@nl
type
label
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@ast
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@en
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@nl
prefLabel
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@ast
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@en
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@nl
P2093
P1476
Inhibitors of the tyrosine kin ...... substituted anilinopyrimidines
@en
P2093
Andrew Mortlock
Catherine Bardelle
Darren Cross
Emma J Williams
Eun Jung Ko
Jason G Kettle
Nicola J Roberts
Peter Robins
Sara Davenport
P304
P356
10.1016/J.BMCL.2008.09.087
P407
P50
P577
2008-09-27T00:00:00Z