Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis
about
Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutantsHeparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadismUnderstanding the substrate specificity of the heparan sulfate sulfotransferases by an integrated biosynthetic and crystallographic approachCrystal structures of MBP fusion proteinsA synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearanceMolecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase.Specific sides to multifaceted glycosaminoglycans are observed in embryonic development.Combinatorial one-pot chemoenzymatic synthesis of heparin.Fusion-protein-assisted protein crystallizationUncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesisRecent advances in sulfotransferase enzyme activity assays.The design and synthesis of new synthetic low-molecular-weight heparins.Analysis of Drosophila glucuronyl C5-epimerase: implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acidRecent progress and applications in glycosaminoglycan and heparin research.Structure Based Substrate Specificity Analysis of Heparan Sulfate 6-O-Sulfotransferases.The physicochemical fingerprint of Necator americanus.Controlled Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides.Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-SulfotransferaseNew tools for carbohydrate sulfation analysis: heparan sulfate 2--sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors
P2860
Q24298022-930DA511-D7E1-4447-BED9-062FA0AF871AQ24307650-548242B2-340D-4545-A496-16494702E0A1Q27028136-590DC14F-053D-4766-B280-1FB75764E8E3Q28271246-3006FB1F-B920-4F06-9B89-C1C394BB6823Q30386218-EC77F591-8C47-4965-9A19-D01B59BFB3F0Q33581252-A65EFB0F-11FB-40C4-A944-D2FD58613985Q33676686-14E068A0-A67E-4E0E-9EAB-F52EFC890768Q34071237-5E6C6A34-280D-4A79-A0BD-C05640A25243Q35232430-53853293-4863-456A-BB17-4E8D672DAFCCQ35841518-BEBCB760-23C9-48D3-AEF7-E11909643F03Q36033168-BEB2D732-43A2-4FE9-9682-C8D44F85C776Q36182302-7BCB3619-8627-45C0-8828-56E5C6DF4805Q37004231-8CA8DD58-2CF4-4EAF-A0B5-FB2188CAF46AQ37348874-2E0865B6-174D-4ACC-8966-D08D20E141DAQ37455553-B1536D4A-D3D9-4C86-9C49-9588E02F40ECQ38406589-DF948CDA-5E4A-4DE1-9CFB-2F15CB313884Q47095105-1D09AD2B-D531-4CF1-B0A2-AD651E18EBACQ52364871-D36A2C46-C048-4DCA-9A4A-60FF864A4E2EQ56395838-95EC3572-C010-4E28-82B7-AFF6BEF908C5Q56833662-905E8696-1FF8-479B-B14C-05AFDACB673F
P2860
Redirecting the substrate specificity of heparan sulfate 2-O-sulfotransferase by structurally guided mutagenesis
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Redirecting the substrate spec ...... tructurally guided mutagenesis
@ast
Redirecting the substrate spec ...... tructurally guided mutagenesis
@en
Redirecting the substrate spec ...... tructurally guided mutagenesis
@nl
type
label
Redirecting the substrate spec ...... tructurally guided mutagenesis
@ast
Redirecting the substrate spec ...... tructurally guided mutagenesis
@en
Redirecting the substrate spec ...... tructurally guided mutagenesis
@nl
prefLabel
Redirecting the substrate spec ...... tructurally guided mutagenesis
@ast
Redirecting the substrate spec ...... tructurally guided mutagenesis
@en
Redirecting the substrate spec ...... tructurally guided mutagenesis
@nl
P2860
P356
P1476
Redirecting the substrate spec ...... tructurally guided mutagenesis
@en
P2093
Heather N Bethea
P2860
P304
18724-18729
P356
10.1073/PNAS.0806975105
P407
P577
2008-11-20T00:00:00Z