Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡ - Wikidata - wikimedia - TriplyDB

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡

http://www.wikidata.org/entity/Q27653357

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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations Expression, characterization, and cellular localization of knowpains, papain-like cysteine proteases of the Plasmodium knowlesi malaria parasite Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches An Unusual Member of the Papain Superfamily: Mapping the Catalytic Cleft of the Marasmius oreades agglutinin (MOA) with a Caspase Inhibitor Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target.Proteolysis at a specific extracellular residue implicates integral membrane CLAG3 in malaria parasite nutrient channels Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.Altered plasmodial surface anion channel activity and in vitro resistance to permeating antimalarial compounds.Novel anti-plasmodial hits identified by virtual screening of the ZINC database.Centenary celebrations article: Cysteine proteases of human malaria parasites.Structure-function of falcipains: malarial cysteine proteases.Structure Based Docking and Molecular Dynamic Studies of Plasmodial Cysteine Proteases against a South African Natural Compound and its Analogs.Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites From crystal to compound: structure-based antimalarial drug discovery.Molecular recognition in chemical and biological systems.Synthesis, antimalarial activity in vitro, and docking studies of novel neolignan derivatives.Predicting binding modes of reversible peptide-based inhibitors of falcipain-2 consistent with structure-activity relationships.The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis.Toward the discovery of inhibitors of babesipain-1, a Babesia bigemina cysteine protease: in vitro evaluation, homology modeling and molecular docking studies.Molecular docking and 3D-quantitative structure activity relationship analyses of peptidyl vinyl sulfones: Plasmodium Falciparum cysteine proteases inhibitors.Analysis of non-peptidic compounds as potential malarial inhibitors against Plasmodial cysteine proteases via integrated virtual screening workflow.An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.Dynamical footprint of falcipain-2 catalytic triad in hemoglobin-β-bound state.Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents.Synthesis of novel benzimidazole acrylonitriles for inhibition of Plasmodium falciparum growth by dual target inhibition.Insight into selectivity of peptidomimetic inhibitors with modified statine core for plasmepsin II of Plasmodium falciparum over human cathepsin D.Structural features of falcipain-3 inhibitors: an in silico study.CA/C1 peptidases of the malaria parasites Plasmodium falciparum and P. berghei and their mammalian hosts--a bioinformatical analysis.Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester.Allosteric Site Inhibitor Disrupting Auto-Processing of Malarial Cysteine Proteases In Silico Study Reveals How E64 Approaches, Binds to, and Inhibits Falcipain-2 of Plasmodium falciparum that Causes Malaria in Humans Cysteine proteases in protozoan parasites

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Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡

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2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family

Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepatica

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