A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
about
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioningGTPase activation of elongation factor EF-Tu by the ribosome during decoding.Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70S RibosomeHead swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sitesStructural basis for TetM-mediated tetracycline resistanceRegulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome RearrangementCrystal structure of elongation factor 4 bound to a clockwise ratcheted ribosomeRefinement of atomic models in high resolution EM reconstructions using Flex-EM and local assessment.Interrupted catalysis: the EF4 (LepA) effect on back-translocation.Common chaperone activity in the G-domain of trGTPase protects L11-L12 interaction on the ribosomeTranslation factor LepA contributes to tellurite resistance in Escherichia coli but plays no apparent role in the fidelity of protein synthesis.Exploring the spatial and temporal organization of a cell's proteomeNavigating the ribosome's metastable energy landscapeEF-G and EF4: translocation and back-translocation on the bacterial ribosome.The bacterial translation stress response.The conserved GTPase LepA contributes mainly to translation initiation in Escherichia coli.Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations.Ribosomal translocation: one step closer to the molecular mechanism.Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases.The ABCs of the ribosome.The evolutionary and functional diversity of classical and lesser-known cytoplasmic and organellar translational GTPases across the tree of lifeFree-energy landscape of reverse tRNA translocation through the ribosome analyzed by electron microscopy density maps and molecular dynamics simulations.The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesisAllosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesisIdentifying conformational states of macromolecules by eigen-analysis of resampled cryo-EM imagesStructure of BipA in GTP form bound to the ratcheted ribosome.Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the Ribosome.Elongation factor 4 remodels the A-site tRNA on the ribosomeFunctional replacement of two highly conserved tetraloops in the bacterial ribosome.West syndrome caused by homozygous variant in the evolutionary conserved gene encoding the mitochondrial elongation factor GUF1Similarity and diversity of translational GTPase factors EF-G, EF4, and BipA: From structure to functionExploring conformational modes of macromolecular assemblies by multiparticle cryo-EM.The paradox of elongation factor 4: highly conserved, yet of no physiological significance?RNA versatility governs tRNA function: Why tRNA flexibility is essential beyond the translation cycle.Taking a Step Back from Back-Translocation: an Integrative View of LepA/EF4's Cellular Function.Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4Identification of two structural elements important for ribosome-dependent GTPase activity of elongation factor 4 (EF4/LepA).EF4 reveals the energy barrier for tRNA back-translocation in the peptidyl transferase centerRibosomal protein L7/L12 is required for GTPase translation factors EF-G, RF3, and IF2 to bind in their GTP state to 70S ribosomes.EF-G catalyzes tRNA translocation by disrupting interactions between decoding center and codon-anticodon duplex.
P2860
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P2860
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@ast
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@en
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@nl
type
label
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@ast
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@en
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@nl
prefLabel
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@ast
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@en
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@nl
P2093
P50
P3181
P356
P1476
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
@en
P2093
Christian M T Spahn
Knud H Nierhaus
Thorsten Mielke
P2888
P3181
P356
10.1038/NSMB.1469
P577
2008-09-01T00:00:00Z
P5875
P6179
1000883248