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Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis

Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis

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Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila Structural Basis of the Interaction of MbtH-like Proteins, Putative Regulators of Nonribosomal Peptide Biosynthesis, with Adenylating Enzymes Structures of Mycobacterium tuberculosis FadD10 Protein Reveal a New Type of Adenylate-forming Enzyme Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial nonribosomal peptide synthetases Dissecting the role of critical residues and substrate preference of a Fatty Acyl-CoA Synthetase (FadD13) of Mycobacterium tuberculosis Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis Identification of functional differences in metabolic networks using comparative genomics and constraint-based models Equilibrium binding and kinetic characterization of putative tetracycline repressor family transcription regulator Fad35R from Mycobacterium tuberculosis Mycolic acid cyclopropanation is essential for viability, drug resistance, and cell wall integrity of Mycobacterium tuberculosis Establishment and validation of whole-cell based fluorescence assays to identify anti-mycobacterial compounds using the Acanthamoeba castellanii-Mycobacterium marinum host-pathogen system An acyl-CoA synthetase in Mycobacterium tuberculosis involved in triacylglycerol accumulation during dormancy Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32 Genome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles.A high-throughput screening fluorescence polarization assay for fatty acid adenylating enzymes in Mycobacterium tuberculosis.Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria.General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.Adenylate-forming enzymes.Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa Microarray expression profile analysis of mRNAs and long non-coding RNAs in pulmonary tuberculosis with different traditional Chinese medicine syndromes Retrobiosynthetic approach delineates the biosynthetic pathway and the structure of the acyl chain of mycobacterial glycopeptidolipids.Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis Metabolic engineering of microorganisms for the production of structurally diverse esters.Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria.Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Conformational dynamics in the Acyl-CoA synthetases, adenylation domains of non-ribosomal peptide synthetases, and firefly luciferase.Advances In Mycobacterium Tuberculosis Therapeutics Discovery Utlizing Structural Biology.Biosynthesis of mycobacterial lipids by polyketide synthases and beyond.Structures of the N-terminal domain of PqsA in complex with anthraniloyl- and 6-fluoroanthraniloyl-AMP: substrate activation in Pseudomonas Quinolone Signal (PQS) biosynthesis.Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit.Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.Cylindrocyclophane biosynthesis involves functionalization of an unactivated carbon center.Fatty Acyl Incorporation in the Biosynthesis of WAP-8294A, a Group of Potent Anti-MRSA Cyclic Lipodepsipeptides.A continuous kinetic assay for adenylation enzyme activity and inhibition.Versatility of acyl-acyl carrier protein synthetases.Detection of Delta-like 1 ligand for the diagnosis of tuberculous meningitis: An effective and rapid diagnostic method.The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism.

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Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis

http://www.wikidata.org/entity/Q27653610

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2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Nature Chemical Biology

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Mechanistic and functional ins ...... in Mycobacterium tuberculosis

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Aneesh Goyal

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Anil Tyagi

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Eerappa Rajakumara

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Malikmohamed Yousuf

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Omita A Trivedi

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Priyanka Verma

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Radhika Gupta

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Rajesh S Gokhale

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Vivek T Natarajan

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P2860

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S

Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases

Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis

Biochemical differentiation of Mycobacterium tuberculosis grown in vivo and in vitro

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

PROCHECK: a program to check the stereochemical quality of protein structures

Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase

The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A

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166-73

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scholarly article

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10.1038/NCHEMBIO.143

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3

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5

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Rajan Sankaranarayanan

Debasisa Mohanty

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2009-03-01T00:00:00Z

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232794811

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1044134422

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19182784

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Mycobacterium tuberculosis

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2644305

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