In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core
about
Physicochemical Properties of Ion Pairs of Biological MacromoleculesA Catalytic Mechanism for D-Tyr-tRNATyrDeacylase Based on the Crystal Structure of Hemophilus influenzae HI0670High Apparent Dielectric Constant Inside a Protein Reflects Structural Reorganization Coupled to the Ionization of an Internal AspCrystallographic Study of Hydration of an Internal Cavity in Engineered Proteins with Buried Polar or Ionizable GroupsCrystal structure of unliganded influenza B virus hemagglutinin.A buried lysine that titrates with a normal pKa: Role of conformational flexibility at the protein-water interface as a determinant of pKavaluesUsing affinity chromatography to engineer and characterize pH-dependent protein switchesThe pKa Values of Acidic and Basic Residues Buried at the Same Internal Location in a Protein Are Governed by Different FactorsArginine residues at internal positions in a protein are always chargedSolvation energetics and conformational change in EF-hand proteinspH-Dependent conformational changes in proteins and their effect on experimental pK(a)s: the case of Nitrophorin 4"Solvent hydrogen-bond occlusion": A new model of polar desolvation for biomolecular energetics.A procedure for the prediction of temperature-sensitive mutants of a globular protein based solely on the amino acid sequence.Experimental pK(a) values of buried residues: analysis with continuum methods and role of water penetrationStabilization of internal charges in a protein: water penetration or conformational change?Structural plasticity of staphylococcal nuclease probed by perturbation with pressure and pH.Structural origins of high apparent dielectric constants experienced by ionizable groups in the hydrophobic core of a proteinCharges in the hydrophobic interior of proteins.Backbone dipoles generate positive potentials in all proteins: origins and implications of the effectHigh apparent dielectric constants in the interior of a protein reflect water penetrationLarge shifts in pKa values of lysine residues buried inside a protein.Conformational consequences of ionization of Lys, Asp, and Glu buried at position 66 in staphylococcal nucleaseStructural reorganization triggered by charging of Lys residues in the hydrophobic interior of a protein.Conformational relaxation and water penetration coupled to ionization of internal groups in proteins.Do salt bridges stabilize proteins? A continuum electrostatic analysis.Interactions in nonnative and truncated forms of staphylococcal nuclease as indicated by mutational free energy changesEvidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft.High tolerance for ionizable residues in the hydrophobic interior of proteins.Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.Heat capacity changes upon burial of polar and nonpolar groups in proteins.Spatial distribution of dielectric shielding in the interior of Pyrococcus furiosus rubredoxin as sampled in the subnanosecond timeframe by hydrogen exchange.Hydration of the folding transition state ensemble of a protein.NMR studies of structure, hydrogen exchange, and main-chain dynamics in a disrupted-core mutant of thioredoxin.Genetic selection reveals the role of a buried, conserved polar residue.Kinetic mechanism of the Rtt109-Vps75 histone acetyltransferase-chaperone complex.The pH dependence of staphylococcal nuclease stability is incompatible with a three-state denaturation model.Energy functions for protein design I: efficient and accurate continuum electrostatics and solvation.
P2860
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P2860
In a staphylococcal nuclease mutant the side-chain of a lysine replacing valine 66 is fully buried in the hydrophobic core
description
1991 nî lūn-bûn
@nan
1991 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@ast
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@en
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@nl
type
label
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@ast
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@en
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@nl
prefLabel
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@ast
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@en
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@nl
P2093
P1476
In a staphylococcal nuclease m ...... buried in the hydrophobic core
@en
P2093
A G Gittis
E E Lattman
W E Stites
P356
10.1016/0022-2836(91)90795-8
P407
P577
1991-09-05T00:00:00Z