High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL
about
Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xLMutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosisStructural insights into the transcription-independent apoptotic pathway of p53Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind LigandsMcl-1-Bim complexes accommodate surprising point mutations via minor structural changesStructural Consequences of β-Amino Acid Preorganization in a Self-Assembling α/β-Peptide: Fundamental Studies of Foldameric Helix BundlesStructural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1Intrinsic Order and Disorder in the Bcl-2 Member Harakiri: Insights into Its Proapoptotic ActivityStructural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based DesignEvaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 DomainStructure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival ProteinsStructure of a complex formed by a protein and a helical aromatic oligoamide foldamer at 2.1 Å resolutionBh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysisA foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomersPeptidic foldamers: ramping up diversityThe functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.Structure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).High conductance values in π-folded molecular junctions.Bridged beta(3)-peptide inhibitors of p53-hDM2 complexation: correlation between affinity and cell permeability.Positional screening and NMR structure determination of side-chain-to-side-chain cyclized β3-peptides.Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening.Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.Selective and potent proteomimetic inhibitors of intracellular protein-protein interactionsIntrinsic Folding Proclivities in Cyclic β-Peptide Building Blocks: Configuration and Heteroatom Effects Analyzed by Conformer-Selective Spectroscopy and Quantum Chemistry.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Dynamics of the BH3-Only Protein Binding Interface of Bcl-xL.Protein Dimerization on a Phosphonated Calix[6]arene Disc.Dual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways.Physiological restraint of Bak by Bcl-xL is essential for cell survival.Structural biology of the intrinsic cell death pathway: what do we know and what is missing?α/β-Peptide foldamers: state of the art.Stabilized helical peptides: overview of the technologies and therapeutic promises.Peptide and peptoid foldamers in medicinal chemistry.An overview of peptide and peptoid foldamers in medicinal chemistry.Homochirality of β-Peptides: A Significant Biomimetic Property of Unnatural Systems.The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.Hydrophobic Binding Hot Spots of Bcl-xL Protein-Protein Interfaces by Cosolvent Molecular Dynamics Simulation.Analysis of Flexibility and Hotspots in Bcl-xL and Mcl-1 Proteins for the Design of Selective Small-Molecule Inhibitors.Solution Observation of Dimerization and Helix Handedness Induction in a Human Carbonic Anhydrase-Helical Aromatic Amide Foldamer Complex.α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.
P2860
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P2860
High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL
description
2009 nî lūn-bûn
@nan
2009 թուականին հրատարակուած գիտական յօդուած
@hyw
2009 թվականին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@ast
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@en
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@nl
type
label
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@ast
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@en
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@nl
prefLabel
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@ast
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@en
High-Resolution Structural Cha ...... Anti-Apoptotic Protein Bcl-xL
@nl
P2093
P2860
P50
P3181
P356
P1476
High-resolution structural cha ...... anti-apoptotic protein Bcl-xL
@en
P2093
Jack D Sadowsky
Kimberly J Peterson-Kaufman
Peter E Czabotar
Peter M Colman
Samuel H Gellman
P2860
P304
P3181
P356
10.1002/ANIE.200805761
P407
P577
2009-01-01T00:00:00Z