Human neuroserpin: structure and time-dependent inhibition
about
Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous systemHigh resolution structure of cleaved Serpin 42 Da from Drosophila melanogasterSerine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behaviorNeonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges.The tempered polymerization of human neuroserpin.Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular DynamicsAAV-mediated overexpression of neuroserpin in the hippocampus decreases PSD-95 expression but does not affect hippocampal-dependent learning and memory.Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system.Structure-function relationship of SW-AT-1, a serpin-type protease inhibitor in silkworm.Embelin binds to human neuroserpin and impairs its polymerisation.Smoothing a rugged protein folding landscape by sequence-based redesign.The plasmin-antiplasmin system: structural and functional aspects.Inhibitory serpins. New insights into their folding, polymerization, regulation and clearance.pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; implications for the control of beta-sheet A and polymerization.The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop.A hydrophobic patch surrounding Trp154 in human neuroserpin controls the helix F dynamics with implications in inhibition and aggregation.Two latent and two hyperstable polymeric forms of human neuroserpin.Encephalopathy with neuroserpin inclusion bodies presenting as progressive myoclonus epilepsy and associated with a novel mutation in the Proteinase Inhibitor 12 geneIdentification and characterization of α1 -antitrypsin in fibrin clots.An analysis approach to identify specific functional sites in orthologous proteins using sequence and structural information: application to neuroserpin reveals regions that differentially regulate inhibitory activity.The serine protease inhibitor neuroserpin regulates the growth and maturation of hippocampal neurons through a non-inhibitory mechanism.On the molecular structure of human neuroserpin polymers.Molecular bases of neuroserpin function and pathology.
P2860
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P2860
Human neuroserpin: structure and time-dependent inhibition
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Human neuroserpin: structure and time-dependent inhibition
@ast
Human neuroserpin: structure and time-dependent inhibition
@en
Human neuroserpin: structure and time-dependent inhibition
@nl
type
label
Human neuroserpin: structure and time-dependent inhibition
@ast
Human neuroserpin: structure and time-dependent inhibition
@en
Human neuroserpin: structure and time-dependent inhibition
@nl
prefLabel
Human neuroserpin: structure and time-dependent inhibition
@ast
Human neuroserpin: structure and time-dependent inhibition
@en
Human neuroserpin: structure and time-dependent inhibition
@nl
P50
P3181
P1476
Human neuroserpin: structure and time-dependent inhibition
@en
P2093
Graziella Sorrentino
P304
P3181
P356
10.1016/J.JMB.2009.02.056
P407
P577
2009-04-24T00:00:00Z