Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme
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Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme.Ubiquitin is a novel substrate for human insulin-degrading enzymeIdentification of the allosteric regulatory site of insulysinMolecular Basis for the Recognition and Cleavages of IGF-II, TGF-α, and Amylin by Human Insulin-Degrading EnzymeDesigned Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of InsulinConformational states and recognition of amyloidogenic peptides of human insulin-degrading enzymeImidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysisAnti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormonesMolecular Basis of Substrate Recognition and Degradation by Human Presequence ProteaseProtective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation.Metabolism of cryptic peptides derived from neuropeptide FF precursors: the involvement of insulin-degrading enzyme.Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activationInsulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic aβ peptide aggregatesMixed dimers of insulin-degrading enzyme reveal a cis activation mechanismStructure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.An Extended Polyanion Activation Surface in Insulin Degrading Enzyme.Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in miceProteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent mannerImpact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications.Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes MellitusMultiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin.Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes.Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue.Multiple functions of insulin-degrading enzyme: a metabolic crosslight?Mechanisms of peptide hydrolysis by aspartyl and metalloproteases.Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plantsResveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42
P2860
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P2860
Molecular Basis of Catalytic Chamber-assisted Unfolding and Cleavage of Human Insulin by Human Insulin-degrading Enzyme
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@ast
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@en
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@nl
type
label
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@ast
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@en
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@nl
prefLabel
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@ast
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@en
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@nl
P2093
P2860
P921
P356
P1476
Molecular Basis of Catalytic C ...... Human Insulin-degrading Enzyme
@en
P2093
Alexander B Schilling
Enrico Malito
Marika Manolopoulou
P2860
P304
P356
10.1074/JBC.M900068200
P407
P50
P577
2009-05-22T00:00:00Z