Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
about
DNA damage in oocytes induces a switch of the quality control factor TAp63α from dimer to tetramerCaught in self-interaction: evolutionary and functional mechanisms of protein homooligomerizationStructure and apoptotic function of p73Interaction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerStructural Basis for ASPP2 Recognition by the Tumor Suppressor p73Structure and Kinetic Stability of the p63 Tetramerization DomainMechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerizationTracing the evolution of the p53 tetramerization domainFunctional interplay between MDM2, p63/p73 and mutant p53Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.Functional states of homooligomers: insights from the evolution of glycosyltransferases.Conservation of DNA-binding specificity and oligomerisation properties within the p53 family.Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene TherapyMechanisms of protein oligomerization, the critical role of insertions and deletions in maintaining different oligomeric statesMultitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes.p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesGenome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.Identification of a novel Mcl-1 protein binding motifp63 and p73, the ancestors of p53.Tracing the protectors path from the germ line to the genome.p53 Isoforms: An Intracellular Microprocessor?Evolutionary, physicochemical, and functional mechanisms of protein homooligomerization.p73 in Cancer.Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.Evolution of p53 transactivation specificity through the lens of a yeast-based functional assayA global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues.Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.Role of p63 in Development, Tumorigenesis and Cancer ProgressionΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells.Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain.Analysis of the oligomeric state and transactivation potential of TAp73α.15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-γ, SMAD2/3, and TAP63 proteins.The consequence of oncomorphic TP53 mutations in ovarian cancer.One billion years of p53/p63/p73 evolution.Tetramer formation in Arabidopsis MADS domain proteins: analysis of a protein-protein interaction network.The tumor suppressor p53: from structures to drug discovery.The role of p63 in cancer, stem cells and cancer stem cells.Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy.
P2860
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P2860
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@ast
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@en
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@nl
type
label
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@ast
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@en
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@nl
altLabel
Structural evolution of p53, p63, and p73: implication for heterotetramer formation
@en
prefLabel
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@ast
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@en
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@nl
P2860
P50
P921
P356
P1476
Structural evolution of p53, p63, and p73: Implication for heterotetramer formation
@en
P2093
Eviatar Natan
Sridharan Rajagopalan
P2860
P304
P356
10.1073/PNAS.0905867106
P407
P577
2009-10-20T00:00:00Z