Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
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Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidasesStructure of tomato wound-induced leucine aminopeptidase sheds light on substrate specificityX-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking InvestigationsThe Plasmodium falciparum malaria M1 alanyl aminopeptidase (PfA-M1): insights of catalytic mechanism and function from MD simulationsIdentification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual ScreeningFingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.Protease-associated cellular networks in malaria parasite Plasmodium falciparum.Proteases in malaria parasites - a phylogenomic perspective.Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.Plant leucine aminopeptidases moonlight as molecular chaperones to alleviate stress-induced damage.The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.Identification of an intracellular M17 family leucine aminopeptidase that is required for virulence in Staphylococcus aureus.Comparative Genomics and Systems Biology of Malaria Parasites Plasmodium.The Activity of a Hexameric M17 Metallo-Aminopeptidase Is Associated With Survival of Mycobacterium tuberculosis.Proteases as regulators of pathogenesis: examples from the Apicomplexa.From crystal to compound: structure-based antimalarial drug discovery.Generation of AMBER force field parameters for zinc centres of M1 and M17 family aminopeptidases.Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in Trypanosoma brucei.Selective inhibition of PfA-M1, over PfA-M17, by an amino-benzosuberone derivative blocks malaria parasites development in vitro and in vivo.Cloning, purification and preliminary crystallographic analysis of the Helicobacter pylori leucyl aminopeptidase-bestatin complex.Modeling of human M1 aminopeptidases for in silico screening of potential Plasmodium falciparum alanine aminopeptidase (PfA-M1) specific inhibitors.Sitagliptin does not inhibit the M1 alanyl aminopeptidase from Plasmodium falciparum.Molecular cloning and characterization of a M17 leucine aminopeptidase of Cryptosporidium parvum.Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression.
P2860
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P2860
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases.
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2010 nî lūn-bûn
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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structure of the Plasmodium fa ...... ting the neutral exopeptidases
@nl
Structure of the Plasmodium fa ...... ing the neutral exopeptidases.
@ast
Structure of the Plasmodium fa ...... ing the neutral exopeptidases.
@en
type
label
Structure of the Plasmodium fa ...... ting the neutral exopeptidases
@nl
Structure of the Plasmodium fa ...... ing the neutral exopeptidases.
@ast
Structure of the Plasmodium fa ...... ing the neutral exopeptidases.
@en
prefLabel
Structure of the Plasmodium fa ...... ting the neutral exopeptidases
@nl
Structure of the Plasmodium fa ...... ing the neutral exopeptidases.
@ast
Structure of the Plasmodium fa ...... ing the neutral exopeptidases.
@en
P2093
P2860
P50
P356
P1476
Structure of the Plasmodium fa ...... ing the neutral exopeptidases.
@en
P2093
Artur Mucha
Christine A Oellig
Colin M Stack
Donald L Gardiner
John P Dalton
Jolanta Grembecka
Jonathan Lowther
Katharine R Trenholme
Pawel Kafarski
Tina Skinner-Adams
P2860
P304
P356
10.1073/PNAS.0911813107
P407
P577
2010-01-21T00:00:00Z