Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation
about
Talin contains a C-terminal calpain2 cleavage site important in focal adhesion dynamicsIntegrin cytoplasmic tail interactionsPost-translational modifications of the progesterone receptorsCentral Region of Talin Has a Unique Fold That Binds Vinculin and ActinThe Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM DomainStructure, Dynamics, Lipid Binding, and Physiological Relevance of the Putative GTPase-binding Domain of Dictyostelium Formin CRIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and TurnoverStructural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)PAK6 targets to cell-cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escapeStructural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interfacePodocyte-associated talin1 is critical for glomerular filtration barrier maintenance.Talins and kindlins: partners in integrin-mediated adhesion.Structural diversity in integrin/talin interactions.Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2.Membrane-induced structural rearrangement and identification of a novel membrane anchor in talin F2F3The tail of integrin activation.Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesThe integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.Multiscale simulations suggest a mechanism for integrin inside-out activation.Affinity of talin-1 for the β3-integrin cytosolic domain is modulated by its phospholipid bilayer environment.A conserved lipid-binding loop in the kindlin FERM F1 domain is required for kindlin-mediated αIIbβ3 integrin coactivation.Subcellular localization of talin is regulated by inter-domain interactionsNMR Characterization and Membrane Interactions of the Loop Region of Kindlin-3 F1 Subdomain.Regulation of integrin-mediated adhesions.Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafishNanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension.Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells.Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activationThe mechanical response of talin.Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: implications for talin activation.Molecular mechanism of inside-out integrin regulationNeutrophil arrest by LFA-1 activationMechanisms of talin-dependent integrin signaling and crosstalkProtein conformation as a regulator of cell-matrix adhesion.Talin and kindlin: the one-two punch in integrin activation.Formins as effector proteins of Rho GTPasesSHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.Non-monotonic cellular responses to heterogeneity in talin protein expression-level.The kindlin 3 pleckstrin homology domain has an essential role in lymphocyte function-associated antigen 1 (LFA-1) integrin-mediated B cell adhesion and migration
P2860
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P2860
Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structure of a double ubiquiti ...... a role in integrin activation
@ast
Structure of a double ubiquiti ...... a role in integrin activation
@en
Structure of a double ubiquiti ...... a role in integrin activation
@nl
type
label
Structure of a double ubiquiti ...... a role in integrin activation
@ast
Structure of a double ubiquiti ...... a role in integrin activation
@en
Structure of a double ubiquiti ...... a role in integrin activation
@nl
prefLabel
Structure of a double ubiquiti ...... a role in integrin activation
@ast
Structure of a double ubiquiti ...... a role in integrin activation
@en
Structure of a double ubiquiti ...... a role in integrin activation
@nl
P2093
P2860
P3181
P356
P1433
P1476
Structure of a double ubiquiti ...... a role in integrin activation
@en
P2093
Benjamin T Goult
Bipin Patel
David R Critchley
Gordon C K Roberts
Igor L Barsukov
J Günter Grossmann
Mohamed Bouaouina
Paul R Elliott
P2860
P304
P3181
P356
10.1038/EMBOJ.2010.4
P407
P577
2010-03-17T00:00:00Z