Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer
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An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificityp53 dynamics upon response element recognition explored by molecular simulations.Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairsInteraction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerStructure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T CellsStructures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elementsAcetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentrationPliable DNA Conformation of Response Elements Bound to Transcription Factor p63Structure of p73 DNA-binding domain tetramer modulates p73 transactivationStructure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertionStructural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactionsTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeSpecific recognition of p53 tetramers by peptides derived from p53 interacting proteinsEarly onset sebaceous carcinoma.Two p53 tetramers bind one consensus DNA response elementLysine120 interactions with p53 response elements can allosterically direct p53 organization.Increasing occurrences and functional roles for high energy purine-pyrimidine base-pairs in nucleic acidsPathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesA novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53A historical account of Hoogsteen base-pairs in duplex DNA.Electron microscopy studies on the quaternary structure of p53 reveal different binding modes for p53 tetramers in complex with DNAStructure-based predictions broadly link transcription factor mutations to gene expression changes in cancers.Structure and stability insights into tumour suppressor p53 evolutionary related proteins.Oxidation of p53 through DNA charge transport involves a network of disulfides within the DNA-binding domain.Molecular dynamic simulation insights into the normal state and restoration of p53 function.Domain-domain interactions in full-length p53 and a specific DNA complex probed by methyl NMR spectroscopy.Radioprobing the conformation of DNA in a p53-DNA complex.Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells.Extensive post-translational modification of active and inactivated forms of endogenous p53.Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest.p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation.ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylationA nanobody modulates the p53 transcriptional program without perturbing its functional architectureRecognition of Local DNA Structures by p53 Protein.Conformations of p53 response elements in solution deduced using site-directed spin labeling and Monte Carlo sampling.The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain.Multi-scale ensemble modeling of modular proteins with intrinsically disordered linker regions: application to p53.Structure and Function of p53-DNA Complexes with Inactivation and Rescue Mutations: A Molecular Dynamics Simulation Study.Sequence-dependent cooperative binding of p53 to DNA targets and its relationship to the structural properties of the DNA targets.
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P2860
Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer
description
2010 nî lūn-bûn
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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
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2010年论文
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name
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@ast
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@en
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@nl
type
label
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@ast
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@en
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@nl
altLabel
Crystal structure of the p53 c ...... e as a self-assembled tetramer
@en
prefLabel
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@ast
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@en
Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
@nl
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P2860
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Crystal Structure of the p53 C ...... e as a Self-Assembled Tetramer
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P2860
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P356
10.1016/J.STR.2009.11.011
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2010-02-10T00:00:00Z