Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2) - Wikidata - wikimedia - TriplyDB

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

http://www.wikidata.org/entity/Q27659942

about

Protein phosphatases and Alzheimer's disease Small molecule tools for functional interrogation of protein tyrosine phosphatases Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated with Autoimmune Diseases Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo LYP inhibits T-cell activation when dissociated from CSK.Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.Oxime-based click chemistry in the development of 3-isoxazolecarboxylic acid containing inhibitors of Yersinia pestis protein tyrosine phosphatase, YopH.Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.Therapeutic potential of targeting the oncogenic SHP2 phosphatase.Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).Oxime-based linker libraries as a general approach for the rapid generation and screening of multidentate inhibitors.CuAAC click chemistry accelerates the discovery of novel chemical scaffolds as promising protein tyrosine phosphatases inhibitors Protein tyrosine phosphatases as potential therapeutic targets.A combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis SHP2 is a target of the immunosuppressant tautomycetin.A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B Hydroxyindole carboxylic acid-based inhibitors for receptor-type protein tyrosine protein phosphatase beta Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor SHP2 phosphatase promotes mast cell chemotaxis toward stem cell factor via enhancing activation of the Lyn/Vav/Rac signaling axis Molecular targets for the treatment of juvenile myelomonocytic leukemia.A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma.Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.Discovery of a Novel Inhibitor of the Protein Tyrosine Phosphatase Shp2.Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function Design, synthesis, biological activity and molecular dynamics studies of specific protein tyrosine phosphatase 1B inhibitors over SHP-2 Targeting protein tyrosine phosphatase SHP2 for the treatment of PTPN11-associated malignancies Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma.Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia.The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.SHP2 phosphatase as a novel therapeutic target for melanoma treatment.Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.

P2860

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P2860

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

http://www.wikidata.org/entity/Q27659942

description

2010 nî lūn-bûn

@nan

2010 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մարտին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@ast

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@en

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@nl

type

label

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@ast

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@en

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@nl

prefLabel

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@ast

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@en

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@nl

P1433

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P2860

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P1433

Journal of Medicinal Chemistry

P1476

Salicylic Acid Based Small Mol ...... Tyrosine Phosphatase-2 (SHP2)

@en

P2093

Andrea M Gunawan

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Li Wu

http://www.w3.org/2001/XMLSchema#string

Lina Wang

http://www.w3.org/2001/XMLSchema#string

Rebecca J Chan

http://www.w3.org/2001/XMLSchema#string

Sarah C Nabinger

http://www.w3.org/2001/XMLSchema#string

Sijiu Liu

http://www.w3.org/2001/XMLSchema#string

Xian Zhang

http://www.w3.org/2001/XMLSchema#string

Yantao He

http://www.w3.org/2001/XMLSchema#string

Yuanshu Dong

http://www.w3.org/2001/XMLSchema#string

Zhenyun Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases

Large-scale structural analysis of the classical human protein tyrosine phosphatome

The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design

P304

2482-93

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scholarly article

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2152395

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P356

10.1021/JM901645U

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P407

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6

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53

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2010-03-25T00:00:00Z

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41506884

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20170098

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P932

2842125

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