Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
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Insights into the molecular evolution of HslU ATPase through biochemical and mutational analysesCombination therapies for combating antimicrobial resistanceAcyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.Structural Switching of Staphylococcus aureus Clp Protease: A KEY TO UNDERSTANDING PROTEASE DYNAMICSStructural insights into the conformational diversity of ClpP from Bacillus subtilisInsights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) ProteinHelix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp ProteaseStructural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triadStructural and Biochemical Analyses of the Eukaryotic Heat Shock Locus V (HslV) from Trypanosoma bruceiStructural Basis of Mycobacterial Inhibition by Cyclomarin ACtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilisStructure of the autophagic E2 enzyme Atg10Arginine phosphorylation marks proteins for degradation by a Clp proteaseA Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureusThe N-terminal domain plays a crucial role in the structure of a full-length human mitochondrial Lon protease.Activated ClpP kills persisters and eradicates a chronic biofilm infectionPostgenomic strategies in antibacterial drug discovery.Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease.ClpXP, an ATP-powered unfolding and protein-degradation machineAntibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZStructure and activation of a heteromeric protease complex.Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes.Escherichia coli ClpB is a non-processive polypeptide translocase.Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered proteaseStructure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P.Advances in MRSA drug discovery: where are we and where do we need to be?Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP PeptidaseRegulated proteolysis in bacterial development.Proteomic signatures in antibiotic research.Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets.Prospects for new antibiotics: a molecule-centered perspective.Dynamics of the ClpP serine protease: a model for self-compartmentalized proteases.Functional Diversity of AAA+ Protease Complexes in Bacillus subtilis.Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines.Acyldepsipeptide antibiotics as a potential therapeutic agent against Clostridium difficile recurrent infections.The development of small-molecule modulators for ClpP protease activity.
P2860
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P2860
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Structures of ClpP in complex ...... eveal its activation mechanism
@ast
Structures of ClpP in complex ...... eveal its activation mechanism
@en
Structures of ClpP in complex ...... eveal its activation mechanism
@nl
type
label
Structures of ClpP in complex ...... eveal its activation mechanism
@ast
Structures of ClpP in complex ...... eveal its activation mechanism
@en
Structures of ClpP in complex ...... eveal its activation mechanism
@nl
prefLabel
Structures of ClpP in complex ...... eveal its activation mechanism
@ast
Structures of ClpP in complex ...... eveal its activation mechanism
@en
Structures of ClpP in complex ...... eveal its activation mechanism
@nl
P2093
P3181
P356
P1476
Structures of ClpP in complex ...... eveal its activation mechanism
@en
P2093
Byung-Gil Lee
Eun Young Park
Heike Brötz-Oesterhelt
Helga Rübsamen-Schaeff
Holger Paulsen
Hyesung Jeon
Kwang Hoon Sung
Kyung-Eun Lee
P2888
P304
P3181
P356
10.1038/NSMB.1787
P577
2010-03-21T00:00:00Z
P5875
P6179
1029358071