Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization

Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization

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http://www.wikidata.org/entity/Q27660340
Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulationsBACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseDeveloping β-secretase inhibitors for treatment of Alzheimer's disease.Fragment informatics and computational fragment-based drug design: an overview and update.De novo design: balancing novelty and confined chemical space.The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.N-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-phenyl)-amides as BACE1 inhibitors: a patent evaluation of WO2013041499.Molecular docking based virtual screening of natural compounds as potential BACE1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis.Protective effects of a piperazine derivative [N-{4-[4-(2-methoxy-phenyl)-piperazin-1-yl]-phenyl} carbamic acid ethyl ester] against aluminium-induced neurotoxicity: insights from in silico and in vivo studies.Effect of sampling on BACE-1 ligands binding free energy predictions via MM-PBSA calculations.Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1'-P2' ligands.Chemometric design to explore pharmacophore features of BACE inhibitors for controlling Alzheimer's disease.
P2860

Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization

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http://www.wikidata.org/entity/Q27660340
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
name
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@ast
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@en
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@nl
type
label
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@ast
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@en
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@nl
prefLabel
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@ast
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@en
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@nl
P1433
P1476
P2093
P304
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P356
P407
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P50
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P5875
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P1476
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2010.03.050
P407
P433
P478
P50
P577
P5875
P698