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New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

http://www.wikidata.org/entity/Q27660594

about

Strength and specificity of the CMBA screening platform for bioactive molecules discovery Connexin 30 expression inhibits growth of human malignant gliomas but protects them against radiation therapy.Structural basis of CX-4945 binding to human protein kinase CK2 Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor Crystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding Mode Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6 Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies Targeting Pim kinases for cancer treatment: opportunities and challenges PIM1 kinase as a target for cancer therapy High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Antitumoral activity of allosteric inhibitors of protein kinase CK2.[Small compounds libraries: a research tool for chemical biology].Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation.Inhibition of Pim1 kinase activation attenuates allergen-induced airway hyperresponsiveness and inflammation Structural and functional determinants of protein kinase CK2α: facts and open questions.Revisiting protein kinase-substrate interactions: Toward therapeutic development.Exploring the prominent performance of CX-4945 derivatives as protein kinase CK2 inhibitors by a combined computational study.Phosphoproteome profile of human lung cancer cell line A549.Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.Pharmacokinetic characterization of CK2 inhibitor CX-4945.

P2860

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P2860

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

http://www.wikidata.org/entity/Q27660594

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@ast

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@en

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@nl

type

label

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@ast

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@en

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@nl

prefLabel

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@ast

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@en

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

@nl

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New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights

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Alex N Bullock

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Céline F Sautel

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David Grierson

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Liliane Mouawad

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Miriam López-Ramos

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Renaud Prudent

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Virginie Moucadel

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3171-3185

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scholarly article

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10.1096/FJ.09-143743

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9

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24

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Panagis Filippakopoulos

Frédéric Schmidt

Jean-Claude Florent

Caroline Barette

Jean-Baptiste Reiser

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2010-04-16T00:00:00Z

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20400536

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