Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation
about
Structural Study of the Complex Stereoselectivity of Human Butyrylcholinesterase for the Neurotoxic V-agentsCrystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesteraseStructures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interfaceMass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bondCrystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel.Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agentsEfforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase.SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides.Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? Insight from the theoretical study.Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors.Structural and electronic aspects of hydrogen bonding in two polymorphs of butylene-N,N'-bis(O,O'-diarylphosphoramidate).A new motif in the N-terminal of acetylcholinesterase triggers amyloid-β aggregation and deposition.Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies.Why is Aged Acetylcholinesterase So Difficult to Reactivate?New therapeutic approaches and novel alternatives for organophosphate toxicity.Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors.Identification of new allosteric sites and modulators of AChE through computational and experimental tools.
P2860
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P2860
Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation
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2010 nî lūn-bûn
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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年論文
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2010年论文
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name
Structural evidence that human ...... un ages through O-dealkylation
@ast
Structural evidence that human ...... un ages through O-dealkylation
@en
Structural evidence that human ...... un ages through O-dealkylation
@nl
type
label
Structural evidence that human ...... un ages through O-dealkylation
@ast
Structural evidence that human ...... un ages through O-dealkylation
@en
Structural evidence that human ...... un ages through O-dealkylation
@nl
prefLabel
Structural evidence that human ...... un ages through O-dealkylation
@ast
Structural evidence that human ...... un ages through O-dealkylation
@en
Structural evidence that human ...... un ages through O-dealkylation
@nl
P2093
P356
P1476
Structural evidence that human ...... un ages through O-dealkylation
@en
P2093
Eugénie Carletti
Florine Dupeux
Marie Trovaslet
Patrick Masson
P304
P356
10.1021/JM901853B
P407
P577
2010-05-27T00:00:00Z