Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay - Wikidata - wikimedia - TriplyDB

Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay

Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay

http://www.wikidata.org/entity/Q27661404

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Ten things you should know about protein kinases: IUPHAR Review 14 Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.Detection of secondary binding sites in proteins using fragment screening Assay development and high-throughput screening of small molecular c-Abl kinase activators.Structure-guided optimization of small molecule c-Abl activators Twenty years on: the impact of fragments on drug discovery.SPLINTS: small-molecule protein ligand interface stabilizers.Moving Beyond Active-Site Detection: MixMD Applied to Allosteric Systems.Biophysics: for HTS hit validation, chemical lead optimization, and beyond.The impact of structural biology in medicine illustrated with four case studies.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Isotope labeling in insect cells.(E)-(2-Chloro-benzyl-idene)amino 2-amino-4-chloro-benzoate.Allosteric BCR-ABL inhibitors in Philadelphia chromosome-positive acute lymphoblastic leukemia: novel opportunities for drug combinations to overcome resistance.Synthesis, kinetic studies and molecular modeling of novel tacrine dimers as cholinesterase inhibitors.Current NMR Techniques for Structure-Based Drug Discovery.Acceleration of protein backbone NMR assignment by combinatorial labeling: Application to a small molecule binding study.The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.Biosensor-based approach to the identification of protein kinase ligands with dual-site modes of action.19F-NMR-Based Dual-Site Reporter Assay for the Discovery and Distinction of Catalytic and Allosteric Kinase Inhibitors.Allosterische Kinaseinhibitoren

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P2860

Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay

http://www.wikidata.org/entity/Q27661404

description

2010 nî lūn-bûn

@nan

2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

@zh-tw

2010年论文

@wuu

name

Binding or bending: distinctio ...... NMR-based conformational assay

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Binding or bending: distinctio ...... NMR-based conformational assay

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Binding or bending: distinctio ...... NMR-based conformational assay

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type

label

Binding or bending: distinctio ...... NMR-based conformational assay

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Binding or bending: distinctio ...... NMR-based conformational assay

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Binding or bending: distinctio ...... NMR-based conformational assay

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prefLabel

Binding or bending: distinctio ...... NMR-based conformational assay

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Binding or bending: distinctio ...... NMR-based conformational assay

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Binding or bending: distinctio ...... NMR-based conformational assay

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P1433

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Journal of the American Chemical Society

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Binding or bending: distinctio ...... NMR-based conformational assay

@en

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Andreas L Marzinzik

http://www.w3.org/2001/XMLSchema#string

André Strauss

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Doriano Fabbro

http://www.w3.org/2001/XMLSchema#string

Gabriele Fendrich

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Jürgen Mestan

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Pascal Furet

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Robert M Grotzfeld

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Sandra W Cowan-Jacob

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Simona Cotesta

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Wolfgang Jahnke

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7043-8

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scholarly article

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10.1021/JA101837N

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20

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132

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2010-05-26T00:00:00Z

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20450175

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