Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
about
One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D.Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts.Allosteric modulators of MEK1: drug design and discovery.Synthesis and biological evaluation of RGD-conjugated MEK1/2 kinase inhibitors for integrin-targeted cancer therapy.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles.Development of Gold-catalyzed [4+1] and [2+2+1]/[4+2] Annulations between Propiolate Derivatives and Isoxazoles.Atom-economic generation of gold carbenes: gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles.
P2860
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P2860
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@ast
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@en
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@nl
type
label
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@ast
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@en
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@nl
prefLabel
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@ast
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@en
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@nl
P2093
P1476
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
@en
P2093
Clifford D Mol
Douglas R Dougan
Lihong Shi
Mark E Adams
Michael B Wallace
Petro Halkowycz
Shawn M O'Connell
Toufike Kanouni
Victoria A Feher
P304
P356
10.1016/J.BMCL.2010.05.058
P407
P577
2010-07-15T00:00:00Z