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Stathmin and Interfacial Microtubule Inhibitors Recognize a Naturally Curved Conformation of Tubulin Dimers

Stathmin and Interfacial Microtubule Inhibitors Recognize a Naturally Curved Conformation of Tubulin Dimers

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Detailed Per-residue Energetic Analysis Explains the Driving Force for Microtubule Disassembly Design and Characterization of Modular Scaffolds for Tubulin Assembly Structural basis of tubulin tyrosination by tubulin tyrosine ligase High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery The free energy profile of tubulin straight-bent conformational changes, with implications for microtubule assembly and drug discovery GDP-to-GTP exchange on the microtubule end can contribute to the frequency of catastrophe.Discovery of biarylaminoquinazolines as novel tubulin polymerization inhibitors New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer The contribution of αβ-tubulin curvature to microtubule dynamics.Designing and Testing of Novel Taxanes to Probe the Highly Complex Mechanisms by Which Taxanes Bind to Microtubules and Cause Cytotoxicity to Cancer Cells Tau Binds to Multiple Tubulin Dimers with Helical Structure.Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors.An overview of tubulin inhibitors that interact with the colchicine binding site Discovery of 4-Aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties.Mechanism for the catastrophe-promoting activity of the microtubule destabilizer Op18/stathmin The tubulin colchicine domain: a molecular modeling perspective.Anti-Microtubule Drugs.Synthesis of the new ring system bispyrido[4',3':4,5]pyrrolo [1,2-a:1',2'-d]pyrazine and its deaza analogue.How to deal with low-resolution target structures: using SAR, ensemble docking, hydropathic analysis, and 3D-QSAR to definitively map the αβ-tubulin colchicine site.Molecular dynamics and tubulin polymerization kinetics study on 1,14-heterofused taxanes: evidence of stabilization of the tubulin head-to-tail dimer-dimer interaction.Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents.Relating nucleotide-dependent conformational changes in free tubulin dimers to tubulin assembly.Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures.Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β-Tubulin.Structure-based approaches for the design of benzimidazole-2-carbamate derivatives as tubulin polymerization inhibitors.Elucidating the mechanism of action of the clinically approved taxanes: a comprehensive comparison of local and allosteric effects.Microtubule dynamics: moving toward a multi-scale approach.Heterogeneous Tau-Tubulin Complexes Accelerate Microtubule Polymerization.Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site.Principles of Shape-Driven Nanostructure Design via Self-Assembly of Protein Building Blocks

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Stathmin and Interfacial Microtubule Inhibitors Recognize a Naturally Curved Conformation of Tubulin Dimers

http://www.wikidata.org/entity/Q27663742

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Stathmin and Interfacial Micro ...... Conformation of Tubulin Dimers

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JBC.M110.141929

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Journal of Biological Chemistry

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Stathmin and interfacial micro ...... conformation of tubulin dimers

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Audrey Dorléans

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Diane Allegro

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Francois Devred

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Laura Sanz

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Marcel Knossow

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Pascale Barbier

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Vincent Peyrot

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P2860

Op18/stathmin caps a kinked protofilament-like tubulin tetramer

Structural plasticity in actin and tubulin polymer dynamics.

Improved methods for building protein models in electron density maps and the location of errors in these models

The 4 A X-ray structure of a tubulin:stathmin-like domain complex

Refined structure of alpha beta-tubulin at 3.5 A resolution

The lattice as allosteric effector: Structural studies of - and -tubulin clarify the role of GTP in microtubule assembly

Structural insight into the inhibition of tubulin by vinca domain peptide ligands

Variations in the colchicine-binding domain provide insight into the structural switch of tubulin

A common protein fold and similar active site in two distinct families of beta-glycanases

Structure of the alpha beta tubulin dimer by electron crystallography

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31672-31681

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4856467

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10.1074/JBC.M110.141929

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41

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José M. Andreu

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2010-07-30T00:00:00Z

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20675373

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