Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes
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Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approachMetabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INTRACELLULAR -O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF -O-LINKED -N-ACETYLGLUCOSAMINIDASEGaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysisDifferential effects of an O-GlcNAcase inhibitor on tau phosphorylationO-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?O-GlcNAc-ylation in the Nuclear Pore Complex.Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates Akt signaling.Multiple tissue-specific roles for the O-GlcNAc post-translational modification in the induction of and complications arising from type II diabetes.O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegansConditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasisMetabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways.Diverse regulation of AKT and GSK-3β by O-GlcNAcylation in various types of cells.O-linked N-acetylglucosamine cycling regulates mitotic spindle organization.Cracking the O-GlcNAc code in metabolism.O-GlcNAc and the cardiovascular system.Rare and unusual glycosylation of peptides and proteins.Protein O-GlcNAcylation in diabetes and diabetic complications.PUGNAc induces protein ubiquitination in C2C12 myotube cells.Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease.The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation.Protein O-GlcNAcylation: emerging mechanisms and functions.Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasisScalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.O-Linked β-N-acetylglucosamine (O-GlcNAc) modification: a new pathway to decode pathogenesis of diabetic retinopathy.Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin.Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human -GlcNAcaseInvolvement of O-GlcNAcylation in the Skeletal Muscle Physiology and Physiopathology: Focus on Muscle Metabolism
P2860
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P2860
Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@ast
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@en
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@nl
type
label
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@ast
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@en
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@nl
prefLabel
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@ast
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@en
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@nl
P2860
P50
P921
P1476
Inhibition of O-GlcNAcase Usin ...... esistance in 3T3-L1 Adipocytes
@en
P2093
Keith A Stubbs
Tracey M Gloster
P2860
P304
P356
10.1016/J.CHEMBIOL.2010.07.006
P577
2010-09-24T00:00:00Z