Structures of the Human GTPase MMAA and Vitamin B 12 -dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation
about
Mitochondrial targets for pharmacological intervention in human diseaseNavigating the B(12) road: assimilation, delivery, and disorders of cobalaminA switch III motif relays signaling between a B12 enzyme and its G-protein chaperoneAutoinhibition and Signaling by the Switch II Motif in the G-protein Chaperone of a Radical B12 EnzymeNovel B(12)-dependent acyl-CoA mutases and their biotechnological potential.Molecular Genetic Characterization of 151 Mut-Type Methylmalonic Aciduria Patients and Identification of 41 Novel Mutations in MUTFunctional characterization and categorization of missense mutations that cause methylmalonyl-CoA mutase (MUT) deficiencyRole of vitamin B12 on methylmalonyl-CoA mutase activityFrom structural biology to designing therapy for inborn errors of metabolismA mechanochemical switch to control radical intermediates.Visualization of a radical B12 enzyme with its G-protein chaperone.Engineered and Native Coenzyme B12-dependent Isovaleryl-CoA/Pivalyl-CoA Mutase.Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases.Structural diversity in the AdoMet radical enzyme superfamily.YeiR: a metal-binding GTPase from Escherichia coli involved in metal homeostasisLabile Low-Molecular-Mass Metal Complexes in Mitochondria: Trials and Tribulations of a Burgeoning FieldSpectrum of Mutations in 60 Saudi Patients with Mut Methylmalonic AcidemiaHigh-throughput structural biology of metabolic enzymes and its impact on human diseases.Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids.Experimental evidence validating the computational inference of functional associations from gene fusion events: a critical survey.Relating localized protein motions to the reaction coordinate in coenzyme B₁₂-dependent enzymes.Molecular architectures and functions of radical enzymes and their (re)activating proteins.Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1.Structural basis of the stereospecificity of bacterial B12-dependent 2-hydroxyisobutyryl-CoA mutase.Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase.Functional and structural characteristics of methylmalonyl-CoA mutase from Pyrococcus horikoshii.Epimerase (Msed_0639) and mutase (Msed_0638 and Msed_2055) convert (S)-methylmalonyl-coenzyme A (CoA) to succinyl-CoA in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate cycle.Dynamic, electrostatic model for the generation and control of high-energy radical intermediates by a coenzyme B₁₂-dependent enzyme.Identification of a novel deletion in the MMAA gene in two Iranian siblings with vitamin B12-responsive methylmalonic acidemia.Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screensG-protein signaling: A switch saves B12 radical status.The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12.Protein destabilization and loss of protein-protein interaction are fundamental mechanisms in cblA-type methylmalonic aciduria.Mutation or knock-down of 17β-hydroxysteroid dehydrogenase type 10 cause loss of MRPP1 and impaired processing of mitochondrial heavy strand transcripts.The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for co-existing respiratory supercomplexes.Switch I-dependent allosteric signaling in a G-protein chaperone-B12 enzyme complex.Unraveling the Mechanism and Regioselectivity of the B12-Dependent Reductive Dehalogenase PceA.Defective MMAA does not protect MUTMUT isomerises L-MM-CoA to SUCC-CoA
P2860
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P2860
Structures of the Human GTPase MMAA and Vitamin B 12 -dependent Methylmalonyl-CoA Mutase and Insight into Their Complex Formation
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2010 nî lūn-bûn
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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年學術文章
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name
Structures of the Human GTPase ...... t into Their Complex Formation
@ast
Structures of the Human GTPase ...... t into Their Complex Formation
@en
Structures of the Human GTPase ...... t into Their Complex Formation
@nl
type
label
Structures of the Human GTPase ...... t into Their Complex Formation
@ast
Structures of the Human GTPase ...... t into Their Complex Formation
@en
Structures of the Human GTPase ...... t into Their Complex Formation
@nl
prefLabel
Structures of the Human GTPase ...... t into Their Complex Formation
@ast
Structures of the Human GTPase ...... t into Their Complex Formation
@en
Structures of the Human GTPase ...... t into Their Complex Formation
@nl
P2093
P2860
P921
P3181
P356
P1476
Structures of the Human GTPase ...... t into Their Complex Formation
@en
P2093
Carina Gileadi
D Sean Froese
Emelie Ugochukwu
Ewelina Krysztofinska
João R C Muniz
Roy A Gravel
Wyatt W Yue
P2860
P304
P3181
P356
10.1074/JBC.M110.177717
P407
P577
2010-12-03T00:00:00Z