Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem - Wikidata - wikimedia - TriplyDB

Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem

Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem

http://www.wikidata.org/entity/Q27666516

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Carbapenems: past, present, and future Crystal Structure of OXA-58 with the Substrate-Binding Cleft in a Closed State: Insights into the Mobility and Stability of the OXA-58 Structure Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam Structural Basis for Carbapenemase Activity of the OXA-23 β-Lactamase from Acinetobacter baumannii Structural Origins of Oxacillinase Specificity in Class D -Lactamases Crystal Structure of Carbapenemase OXA-58 from Acinetobacter baumannii The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity Structural basis for carbapenem-hydrolyzing mechanisms of carbapenemases conferring antibiotic resistance Class D β-lactamases: a reappraisal after five decades A fluorescent carbapenem for structure function studies of penicillin-binding proteins, β-lactamases, and β-lactam sensors.Classification of Beta-lactamases and penicillin binding proteins using ligand-centric network models.Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.Site-saturation mutagenesis of position V117 in OXA-1 β-lactamase: effect of side chain polarity on enzyme carboxylation and substrate turnover.Structural Basis for Enhancement of Carbapenemase Activity in the OXA-51 Family of Class D β-Lactamases.Crystallization and preliminary diffraction studies of SFC-1, a carbapenemase conferring antibiotic resistance.Class D β-lactamases do exist in Gram-positive bacteria.Clinical Variants of the Native Class D β-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against Carbapenems The different inhibition mechanisms of OXA-1 and OXA-24 β-lactamases are determined by the stability of active site carboxylated lysine.OXA β-lactamases.The role of conserved surface hydrophobic residues in the carbapenemase activity of the class D β-lactamases.Acquired Class D β-Lactamases.Hydrolytic mechanism of OXA-58 enzyme, a carbapenem-hydrolyzing class D β-lactamase from Acinetobacter baumannii.A Nosocomial Outbreak of Extensively Drug Resistant (XDR) Acinetobacter baumannii Isolates Containing blaOXA-237 Encoded on a Plasmid.Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.Exploring the potential of boronic acids as inhibitors of OXA-24/40 β-lactamase.Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D β-Lactamase of Acinetobacter baumannii.OXA-207, a novel OXA-24 variant with reduced catalytic efficiency against carbapenems in Acinetobacter pittii from Spain.Common clinical substitutions enhance the carbapenemase activity of OXA-51-like class D β-lactamases from Acinetobacter spp.Structural studies on New Delhi Metallo-β-lactamase (NDM-2) suggest old β-lactam, penicillin to be better antibiotic for NDM-2-harbouring Acinetobacter baumanni.The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239.A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation.A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation

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Structures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with Doripenem

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2011 թվականի մարտին հրատարակված գիտական հոդված

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Structures of the Class D Carb ...... nnii in Complex with Doripenem

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Structures of the Class D Carb ...... nnii in Complex with Doripenem

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Structures of the Class D Carb ...... nnii in Complex with Doripenem

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Structures of the Class D Carb ...... nnii in Complex with Doripenem

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Structures of the Class D Carb ...... nnii in Complex with Doripenem

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Caleb J Ortega

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David A Leonard

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Kyle D Schneider

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Rachel A Powers

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P2860

A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

Updated functional classification of beta-lactamases

Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis

Carbapenemases: the versatile beta-lactamases

Insights into class D beta-lactamases are revealed by the crystal structure of the OXA10 enzyme from Pseudomonas aeruginosa

Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem

Critical involvement of a carbamylated lysine in catalytic function of class D -lactamases

Structural basis for imipenem inhibition of class C beta-lactamases.

Comparison of -lactamases of classes A and D: 1.5-A crystallographic structure of the class D OXA-1 oxacillinase

Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1

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Robert A Bonomo

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Acinetobacter baumannii

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3057435

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