Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors

Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors

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http://www.wikidata.org/entity/Q27666917
Discovery of Novel Irreversible Inhibitors of Interleukin (IL)-2-inducible Tyrosine Kinase (Itk) by Targeting Cysteine 442 in the ATP PocketIdentification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping StrategyOxyfunctionalization of pyridine derivatives using whole cells of Burkholderia sp. MAK1Inhibitors of BTK and ITK: state of the new drugs for cancer, autoimmunity and inflammatory diseases.Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.Bruton's TK inhibitors: structural insights and evolution of clinical candidates.Substrate recognition of PLCγ1 via a specific docking surface on Itk.Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases.Approaches to efficiently estimate solvation and explicit water energetics in ligand binding: the use of WaterMap.Advances in the design of ITK inhibitors.Inducible tyrosine kinase inhibitors: a review of the patent literature (2010 - 2013).Structure-functional prediction and analysis of cancer mutation effects in protein kinases.Rapid decomposition and visualisation of protein-ligand binding free energies by residue and by water.A Role for Hydration in Interleukin-2 Inducible T Cell Kinase (Itk) Selectivity.Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition.
P2860

Discovery and structure-activity relationship of 3-aminopyrid-2-ones as potent and selective interleukin-2 inducible T-cell kinase (Itk) inhibitors

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http://www.wikidata.org/entity/Q27666917
description
2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
@ast
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
@en
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
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type
label
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
@ast
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
@en
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
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prefLabel
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
@ast
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
@en
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921
P356
P1433
P1476
Discovery and structure-activi ...... T-cell kinase (Itk) inhibitors
@en
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P921