Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein
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Impact of TRIM5α in vivoStructure of the rhesus monkey TRIM5 PRYSPRY domain, the HIV capsid recognition moduleStructural insight into HIV-1 capsid recognition by rhesus TRIM5Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α SpecificityA unique spumavirus Gag N-terminal domain with functional properties of orthoretroviral matrix and capsidStructural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid latticeFates of retroviral core components during unrestricted and TRIM5-restricted infectionTracking interspecies transmission and long-term evolution of an ancient retrovirus using the genomes of modern mammalsRhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral coreApparent effect of rabbit endogenous lentivirus type K acquisition on retrovirus restriction by lagomorph Trim5αsPandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.Functional evidence for the involvement of microtubules and dynein motor complexes in TRIM5α-mediated restriction of retroviruses.Host and viral determinants of Mx2 antiretroviral activityIntracellular immunity: finding the enemy within--how cells recognize and respond to intracellular pathogensAssisted evolution enables HIV-1 to overcome a high TRIM5α-imposed genetic barrier to rhesus macaque tropism.Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity.The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoatingPotent restriction of HIV-1 and SIVmac239 replication by African green monkey TRIM5α.Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomersRING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoatingEvolutionary and Functional Analysis of Old World Primate TRIM5 Reveals the Ancient Emergence of Primate Lentiviruses and Convergent Evolution Targeting a Conserved Capsid InterfaceThe Ty1 Retrotransposon Restriction Factor p22 Targets Gag.Role of Human TRIM5α in Intrinsic Immunity.Structure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid.The gammaretroviral p12 protein has multiple domains that function during the early stages of replication.Inhibition of reverse transcriptase activity increases stability of the HIV-1 core.Cyclophilin A-dependent restriction to capsid N121K mutant human immunodeficiency virus type 1 in a broad range of cell linesA comparison of murine leukemia viruses that escape from human and rhesus macaque TRIM5αs.Contributions of Charged Residues in Structurally Dynamic Capsid Surface Loops to Rous Sarcoma Virus Assembly.Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses.Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors.Design of a novel integration-deficient lentivector technology that incorporates genetic and posttranslational elements to target human dendritic cells.N-linked glycosylation protects gammaretroviruses against deamination by APOBEC3 proteins.HIV-1 Capsid Stabilization Assay.Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction.Human cytosolic extracts stabilize the HIV-1 coreA general model for retroviral capsid pattern recognition by TRIM5 proteins.
P2860
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P2860
Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein
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2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@ast
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@en
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
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type
label
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@ast
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@en
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@nl
prefLabel
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@ast
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@en
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@nl
P2093
P2860
P3181
P1433
P1476
Novel Escape Mutants Suggest a ...... Leukemia Virus Capsid Protein
@en
P2093
Ian A Taylor
Kate Holden-Dye
Melvyn W Yap
Sadayuki Ohkura
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1002011
P577
2011-03-01T00:00:00Z