Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
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Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG IA Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMPStructures of inactive CRP species reveal the atomic details of the allosteric transition that discriminates cyclic nucleotide second messengersThe auto-inhibitory role of the EPAC hinge helix as mapped by NMRCrystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egressDouble electron-electron resonance reveals cAMP-induced conformational change in HCN channels.Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: insights for cGMP-dependent protein kinase agonist design.cGMP-dependent protein kinase I gamma encodes a nuclear localization signal that regulates nuclear compartmentation and function.Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution.The role of cGMP signalling in regulating life cycle progression of Plasmodium.Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase IIA secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channelsCrystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.The switch helix: a putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase.Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissectionsNitration of tyrosine 247 inhibits protein kinase G-1α activity by attenuating cyclic guanosine monophosphate binding.The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43.Holistic Methods for the Analysis of cNMP Effects.Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).Crystal structure of cGMP-dependent protein kinase Iβ cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation.Structural Basis of Analog Specificity in PKG I and II.The crystal structures of PKG Iβ (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding.Switching Cyclic Nucleotide-Selective Activation of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Holoenzyme Reveals Distinct Roles of Tandem Cyclic Nucleotide-Binding Domains.cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors.An N-terminally truncated form of cyclic GMP-dependent protein kinase Iα (PKG Iα) is monomeric, autoinhibited, and provides a model for activation.Establishing a Split Luciferase Assay for Proteinkinase G (PKG) Interaction Studies.The Structure of the Full-Length Tetrameric PKA Regulatory RII Complex Reveals the Mechanism of Allosteric PKA ActivationNeutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator.
P2860
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P2860
Co-Crystal Structures of PKG Iβ (92–227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
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2011 nî lūn-bûn
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2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@ast
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@en
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@nl
type
label
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@ast
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@en
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@nl
prefLabel
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@ast
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@en
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@nl
P2093
P2860
P1433
P1476
Co-Crystal Structures of PKG I ...... s of Cyclic-Nucleotide Binding
@en
P2093
Dar-Chone Chow
Darren E Casteel
Gilbert Huang
Jeffrey J Headd
Jeong Joo Kim
Nicholas Gene Brown
Peter Zwart
Ronnie Kuo Ren
Taek Hun Kwon
P2860
P304
P356
10.1371/JOURNAL.PONE.0018413
P407
P577
2011-04-19T00:00:00Z