Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RI
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Human IgG4: a structural perspectiveAn Engineered Disulfide Bond Reversibly Traps the IgE-Fc3-4 in a Closed, Nonreceptor Binding ConformationAccelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitorCa2+-dependent Structural Changes in the B-cell Receptor CD23 Increase Its Affinity for Human Immunoglobulin EConformational plasticity at the IgE-binding site of the B-cell receptor CD23A range of C∊3–C∊4 interdomain angles in IgE Fc accommodate binding to its receptor CD23Human immunoglobulin E flexes between acutely bent and extended conformations.A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma100 Years later: Celebrating the contributions of x-ray crystallography to allergy and clinical immunology.IgE binds asymmetrically to its B cell receptor CD23Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.Development of small molecules to target the IgE:FcεRI protein-protein interaction in allergies.Structural and Physical Basis for Anti-IgE Therapy.Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of allergic airway inflammation.Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.General mechanism for modulating immunoglobulin effector function.Antibodies and their receptors: different potential roles in mucosal defense.Critical and direct involvement of the CD23 stalk region in IgE binding.Targeting B cells and autoantibodies in the therapy of autoimmune diseases.Type I and type II Fc receptors regulate innate and adaptive immunity.Dendritic cells revisited in human allergic rhinitis and asthma.Fcγ receptor pathways during active and passive immunization.Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII.The Role and Function of Fcγ Receptors on Myeloid Cells.Anti-retroviral antibody FcγR-mediated effector functions.Structure of the omalizumab Fab.Optimization of protein-protein docking for predicting Fc-protein interactions.Immuno-evasive tactics by schistosomes identify an effective allergy preventative.High affinity targeting of CD23 inhibits IgE synthesis in human B cells.Thermal sensitivity and flexibility of the Cε3 domains in immunoglobulin E.Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction.Fcγ Receptor Function and the Design of Vaccination Strategies.Diversification of IgG effector functions.Chimeric Antigen Receptors Based on Low Affinity Mutants of FcεRI Re-direct T Cell Specificity to Cells Expressing Membrane IgE
P2860
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P2860
Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc RI
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@ast
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@en
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@nl
type
label
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@ast
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@en
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@nl
prefLabel
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@ast
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@en
Crystal structure of IgE bound ...... h high affinity receptor Fc RI
@nl
P2093
P2860
P50
P3181
P356
P1476
Crystal structure of IgE bound ...... h high affinity receptor FcεRI
@en
P2093
Alistair J Henry
Amanda Oxbrow
Brian J Sutton
Daopeng Yuan
Katharine Cain
Marie O Y Pang
Stella M Fabiane
P2860
P304
12686-12691
P3181
P356
10.1073/PNAS.1207278109
P407
P577
2012-07-16T00:00:00Z