2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation
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Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of MyeloperoxidasePharmacology and Clinical Drug Candidates in Redox MedicineOxidative stress and free radicals in COPD--implications and relevance for treatmentInhibition of myeloperoxidase: evaluation of 2H-indazoles and 1H-indazolones.Potent Reversible Inhibition of Myeloperoxidase by Aromatic HydroxamatesMyeloperoxidase: a front-line defender against phagocytosed microorganismsMyeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer ChemotherapyRational drug design applied to myeloperoxidase inhibition.Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic acid hydrazide analogs.Interactions of hydrogen sulfide with myeloperoxidaseESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight FragmentsPhytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms.Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development.Autoantibodies to posttranslational modifications in rheumatoid arthritis.Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids.Posttranslational protein modifications by reactive nitrogen and chlorine species and strategies for their prevention and elimination.Characterization and antioxidant properties of six Algerian propolis extracts: ethyl acetate extracts inhibit myeloperoxidase activity.Methods for measuring myeloperoxidase activity toward assessing inhibitor efficacy in living systems.Characterization of chemical features of potent myeloperoxidase inhibitors.Hybrid molecules inhibiting myeloperoxidase activity and serotonin reuptake: a possible new approach of major depressive disorders with inflammatory syndrome.Mechanism of reaction of chlorite with mammalian heme peroxidasesZinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization.Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase.Inflammatory bowel disease therapies and gut function in a colitis mouse model.Ceruloplasmin is an endogenous inhibitor of myeloperoxidase.Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications.Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes.Protein Posttranslational Modifications: Roles in Aging and Age-Related Disease.Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.Myeloperoxidase inhibition ameliorates multiple system atrophy-like degeneration in a transgenic mouse model.Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice.
P2860
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P2860
2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation
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2011 nî lūn-bûn
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2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
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name
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@ast
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@en
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@nl
type
label
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@ast
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@en
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@nl
prefLabel
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@ast
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@en
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@nl
P2093
P2860
P356
P1476
2-Thioxanthines Are Mechanism- ...... ive Stress during Inflammation
@en
P2093
Alexandra Bernlind
Anna-Karin Tidén
Anthony J Kettle
Francoise Auchère
Guy N L Jameson
Henrietta Norman
Håkan Eriksson
Louisa V Forbes
Louise N Paton
Mats Svensson
P2860
P304
P356
10.1074/JBC.M111.266981
P407
P577
2011-10-28T00:00:00Z