Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
about
Single-particle cryo-EM of calcium release channels: structural validationDisease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interfaceStructural and functional conservation of key domains in InsP3 and ryanodine receptorsStructural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketStructural insights into the human RyR2 N-terminal region involved in cardiac arrhythmiasA bead aggregation assay for detection of low-affinity protein-protein interactions reveals interactions between N-terminal domains of inositol 1,4,5-trisphosphate receptorsToward a high-resolution structure of IP₃R channel.Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptorsStimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3Bilayer measurement of endoplasmic reticulum Ca2+ channels.Regulation of ryanodine receptor RyR2 by protein-protein interactions: prediction of a PKA binding site on the N-terminal domain of RyR2 and its relation to disease causing mutationsIdentification of functionally critical residues in the channel domain of inositol trisphosphate receptorsGating machinery of InsP3R channels revealed by electron cryomicroscopyRyanodine receptors: structure and function.Themes and variations in ER/SR calcium release channels: structure and function.Ryanodine receptor calcium release channels: lessons from structure-function studies.Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.Structural organization of signalling to and from IP3 receptors.Structure of IP3R channel: high-resolution insights from cryo-EM.Multivalent benzene polyphosphate derivatives are non-Ca2+-mobilizing Ins(1,4,5)P3 receptor antagonists.IP3 receptor mutations and brain diseases in human and rodents.Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif.Contribution of phosphates and adenine to the potency of adenophostins at the IP₃ receptor: synthesis of all possible bisphosphates of adenophostin A.Synthesis of dimeric analogs of adenophostin A that potently evoke Ca2+ release through IP3 receptorsRoles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination.PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography.A novel gain-of-function mutation in the ITPR1 suppressor domain causes spinocerebellar ataxia with altered Ca2+ signal patterns.Revisiting channel allostery: a coherent mechanism in IP₃ and ryanodine receptors.Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders.Ryanodine receptor resolution revolution: Implications for InsP3 receptors?The conserved Arg241-Glu439 salt bridge determines flexibility of the inositol 1,4,5-trisphosphate receptor binding core in the ligand-free state.
P2860
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P2860
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@ast
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@en
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@nl
type
label
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@ast
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@en
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@nl
prefLabel
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@ast
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@en
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@nl
P2093
P2860
P921
P3181
P356
P1476
Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor
@en
P2093
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2112
P577
2011-09-04T00:00:00Z
P5875
P6179
1004576395