TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors
about
Unique Flap Conformation in an HIV-1 Protease with High-Level Darunavir Resistance.Organic carbamates in drug design and medicinal chemistryC-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including DarunavirInvestigational protease inhibitors as antiretroviral therapies.Pharmacokinetic enhancers in HIV therapeutics.Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDSMechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease
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P2860
TMC310911, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor, Shows In Vitro an Improved Resistance Profile and Higher Genetic Barrier to Resistance Compared with Current Protease Inhibitors
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
@ast
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
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TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
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type
label
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
@ast
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
@en
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
@nl
prefLabel
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
@ast
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
@en
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
@nl
P2093
P2860
P356
P1476
TMC310911, a Novel Human Immun ...... th Current Protease Inhibitors
@en
P2093
Araz Raoof
Celia A Schiffer
Gaston Picchio
Guenter Kraus
Herwig Van Marck
Inge Dierynck
Madhavi N L Nalam
Marcia Van Ginderen
Tim H M Jonckers
P2860
P304
P356
10.1128/AAC.00748-11
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P577
2011-12-01T00:00:00Z