Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity - Wikidata - wikimedia - TriplyDB

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

http://www.wikidata.org/entity/Q27674636

about

Reactivation of oxidized PTP1B and PTEN by thioredoxin 1 Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction Cellular biochemistry methods for investigating protein tyrosine phosphatases Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling Regulation of A20 and other OTU deubiquitinases by reversible oxidation The Sensitive Balance between the Fully Folded and Locally Unfolded Conformations of a Model Peroxiredoxin Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.Cysteines under ROS attack in plants: a proteomics view.Selective inhibition of the function of tyrosine-phosphorylated STAT3 with a phosphorylation site-specific intrabody ER-PM connections: sites of information transfer and inter-organelle communication Metabolic regulation by protein tyrosine phosphatases.The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.The hepatitis C virus modulates insulin signaling pathway in vitro promoting insulin resistance Redox-based probes as tools to monitor oxidized protein tyrosine phosphatases in living cells.Tuning of peroxiredoxin catalysis for various physiological roles Recombinant antibodies to histone post-translational modifications Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery Protein-tyrosine phosphatase 1B substrates and metabolic regulation Redox regulation of protein kinases.Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies.Methods to monitor classical protein-tyrosine phosphatase oxidation.An immunochemical approach to detect oxidized protein tyrosine phosphatases using a selective C-nucleophile tag Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction.Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.PTP1B: a simple enzyme for a complex world.The Use of Antibodies in Small-Molecule Drug Discovery.Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1B.Chemical approaches to discovery and study of sources and targets of hydrogen peroxide redox signaling through NADPH oxidase proteins.Targeting Tyrosine Phosphatases: Time to End the Stigma.Covalent inhibition of protein tyrosine phosphatases.An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein.Strategies to make protein serine/threonine (PP1, calcineurin) and tyrosine phosphatases (PTP1B) druggable: achieving specificity by targeting substrate and regulatory protein interaction sites.Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2.Estimation of kinetic parameters related to biochemical interactions between hydrogen peroxide and signal transduction proteins.Insulin-dependent H2O2 production is higher in muscle fibers of mice fed with a high-fat diet.ATF7 is stabilized during mitosis in a CDK1-dependent manner and contributes to cyclin D1 expression.Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice.Protein phosphatases, from molecules to networks.

P2860

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P2860

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

http://www.wikidata.org/entity/Q27674636

description

2011 nî lūn-bûn

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2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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Conformation-Sensing Antibodie ...... hibit Its Phosphatase Activity

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J.CELL.2011.08.036

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Conformation-sensing antibodie ...... hibit its phosphatase activity

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Aftabul Haque

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Annette Salmeen

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David Barford

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Nicholas K Tonks

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P2860

Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

Insulin signalling and the regulation of glucose and lipid metabolism

PTP1B regulates leptin signal transduction in vivo

Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells

PTP1B regulates Eph receptor function and trafficking

Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction

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10.1016/J.CELL.2011.08.036

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1

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Jannik N Andersen

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