Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
about
Out-of-register -sheets suggest a pathway to toxic amyloid aggregatesA Fibril-Like Assembly of Oligomers of a Peptide Derived from β-AmyloidAn Atomistic View of Amyloidogenic Self-assembly: Structure and Dynamics of Heterogeneous Conformational States in the Pre-nucleation Phase.Protein-Protein Interactions Mediated by Helical Tertiary Structure Motifs.Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers.Anatomy of β-strands at protein-protein interfaces.Cross dimerization of amyloid-β and αsynuclein proteins in aqueous environment: a molecular dynamics simulations study.Structure-activity relationships for a series of compounds that inhibit aggregation of the Alzheimer's peptide, Aβ42Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.γ-AApeptide-based small-molecule ligands that inhibit Aβ aggregation.Heterodivalent linked macrocyclic β-sheets with enhanced activity against Aβ aggregation: two sites are better than one.Diversification of β-Augmentation Interactions between CDI Toxin/Immunity ProteinsRegulation of protein-ligand binding affinity by hydrogen bond pairing.The supramolecular chemistry of β-sheets.Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch.Mechanism of IAPP amyloid fibril formation involves an intermediate with a transient β-sheet.Square channels formed by a peptide derived from transthyretinPolymorphism of oligomers of a peptide from β-amyloid.Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis.Inhibition of β-amyloid peptide self-assembly and cytotoxicity by poly(LVFF-co-β-amino ester).Chiral recognition in amyloid fiber growth.PPII Helical Peptidomimetics Templated by Cation-π Interactions.Membrane disordering is not sufficient for membrane permeabilization by islet amyloid polypeptide: studies of IAPP(20-29) fragmentsNovel insight into streptozotocin-induced diabetic rats from the protein misfolding perspectiveInduced folding of protein-sized foldameric β-sandwich models with core β-amino acid residues.Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils.Assembly of Peptides Derived from β-Sheet Regions of β-Amyloid.Coassembly of Peptides Derived from β-Sheet Regions of β-AmyloidDe novo design of self-assembling foldamers that inhibit heparin-protein interactions.β-Hairpin mimics containing a piperidine-pyrrolidine scaffold modulate the β-amyloid aggregation process preserving the monomer species.Z-Selective olefin metathesis on peptides: investigation of side-chain influence, preorganization, and guidelines in substrate selectionNew charge-bearing amino acid residues that promote β-sheet secondary structure.A Synthetic Loop Replacement Peptide That Blocks Canonical NF-κB Signaling.Formation of a pseudo-β-hairpin motif utilizing the Ant-Pro reverse turn: consequences of stereochemical reordering.Prion-Like Domains in Phagobiota.Inhibiting and reversing amyloid-β peptide (1-40) fibril formation with gramicidin S and engineered analogues.Assemblies of amyloid-β30-36 hexamer and its G33V/L34T mutants by replica-exchange molecular dynamics simulation.Toward a Soluble Model System for the Amyloid State.
P2860
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P2860
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@ast
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@en
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@nl
type
label
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@ast
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@en
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@nl
prefLabel
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@ast
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@en
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@nl
P2093
P2860
P3181
P356
P1433
P1476
Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity
@en
P2093
James S Nowick
Pin-Nan Cheng
P2860
P2888
P304
P3181
P356
10.1038/NCHEM.1433
P577
2012-11-01T00:00:00Z
P5875
P6179
1049353604