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Visualizing Group II Intron Catalysis through the Stages of Splicing

Visualizing Group II Intron Catalysis through the Stages of Splicing

http://www.wikidata.org/entity/Q27674728

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CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feast Solving nucleic acid structures by molecular replacement: examples from group II intron studies Splicing fidelity: DEAD/H-box ATPases as molecular clocks Crystal structure of group II intron domain 1 reveals a template for RNA assembly Crystal structure of Prp8 reveals active site cavity of the spliceosome Role of helical constraints of the EBS1-IBS1 duplex of a group II intron on demarcation of the 5' splice site NMR structure of the 5' splice site in the group IIB intron Sc.ai5 --conformational requirements for exon-intron recognition Core structure of the U6 small nuclear ribonucleoprotein at 1.7-Å resolution The Role of Mg(II) in DNA Cleavage Site Recognition in Group II Intron Ribozymes Cryo-EM structure of the spliceosome immediately after branching Molecular architecture of the Saccharomyces cerevisiae activated spliceosome Structure of a group II intron in complex with its reverse transcriptase Visualizing the ai5γ group IIB intron Mg2+ ions: do they bind to nucleobase nitrogens?Hierarchy of RNA functional dynamics.Crystal structure of a eukaryotic group II intron lariat RNA catalyses nuclear pre-mRNA splicing Calcium inhibition of ribonuclease H1 two-metal ion catalysis In-line alignment and Mg²⁺ coordination at the cleavage site of the env22 twister ribozyme.Mechanisms and Regulation of Alternative Pre-mRNA Splicing Evidence for a group II intron-like catalytic triplex in the spliceosome Now on display: a gallery of group II intron structures at different stages of catalysis Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution Structural features of a 3' splice site in influenza a Retrohoming of a Mobile Group II Intron in Human Cells Suggests How Eukaryotes Limit Group II Intron Proliferation Native Purification and Analysis of Long RNAs Specificity and catalysis hardwired at the RNA-protein interface in a translational proofreading enzyme.Differential Assembly of Catalytic Interactions within the Conserved Active Sites of Two Ribozymes.An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.The spliceosome catalyzes debranching in competition with reverse of the first chemical reaction Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution Predicted group II intron lineages E and F comprise catalytically active ribozymes.Enhanced group II intron retrohoming in magnesium-deficient Escherichia coli via selection of mutations in the ribozyme core.Principles of ion recognition in RNA: insights from the group II intron structures.RNA Bricks--a database of RNA 3D motifs and their interactions RNA processing and decay in plastids.A day in the life of the spliceosome Structural studies of the spliceosome: zooming into the heart of the machine.Nucleic acid catalysis: metals, nucleobases, and other cofactors.Activating the branch-forming splicing pathway by reengineering the ribozyme component of a natural group II intron.

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Visualizing Group II Intron Catalysis through the Stages of Splicing

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2012 nî lūn-bûn

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2012年の論文

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The dispersal of five group II introns among natural populations of Escherichia coli

A general two-metal-ion mechanism for catalytic RNA

MolProbity: all-atom structure validation for macromolecular crystallography

Tertiary architecture of the Oceanobacillus iheyensis group II intron

PHENIX: a comprehensive Python-based system for macromolecular structure solution

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

A compact RNA tertiary structure contains a buried backbone-K+ complex

Crystal Structure of a Self-Spliced Group II Intron

Structural basis for exon recognition by a group II intron

Structure of the yeast U2/U6 snRNA complex

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