Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV)
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Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit bindingTargeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4--The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistanceHuman coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: homology modelling and molecular dynamic studies.Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.Potential Broad Spectrum Inhibitors of the Coronavirus 3CLpro: A Virtual Screening and Structure-Based Drug Design Study.X-Ray Structure and Inhibition of 3C-like Protease from Porcine Epidemic Diarrhea Virus.Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors.Future treatment strategies for novel Middle East respiratory syndrome coronavirus infection.Structural basis for the development of SARS 3CL protease inhibitors from a peptide mimic to an aza-decaline scaffold.Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site.
P2860
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P2860
Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV)
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Discovery, synthesis, and stru ...... yndrome coronavirus (SARS-CoV)
@en
Discovery, synthesis, and stru ...... yndrome coronavirus (SARS-CoV)
@nl
type
label
Discovery, synthesis, and stru ...... yndrome coronavirus (SARS-CoV)
@en
Discovery, synthesis, and stru ...... yndrome coronavirus (SARS-CoV)
@nl
prefLabel
Discovery, synthesis, and stru ...... yndrome coronavirus (SARS-CoV)
@en
Discovery, synthesis, and stru ...... yndrome coronavirus (SARS-CoV)
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Discovery, synthesis, and stru ...... avirus (SARS-CoV) 3CL protease
@en
P2093
Aimee Eggler
Anna M Mielech
Eric S Dawson
Jon Jacobs
Mark Turlington
Peter Chase
Peter Hodder
S Adrian Saldanha
Shaun R Stauffer
Susan C Baker
P2860
P304
P3181
P356
10.1021/JM301580N
P407
P577
2013-01-03T00:00:00Z