Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
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The emerging roles of inositol pyrophosphates in eukaryotic cell physiologyThe enzymes of human diphosphoinositol polyphosphate metabolismBiosynthesis and possible functions of inositol pyrophosphates in plantsStructural insight into inositol pyrophosphate turnoverThe Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungiConformational Changes in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase upon Substrate Binding: ROLE OF N-TERMINAL LOBE AND ENANTIOMERIC SUBSTRATE PREFERENCEFirst synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinaseSynthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug DiscoveryIP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase familySynthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride FormationStructural basis for precursor protein-directed ribosomal peptide macrocyclizationRegulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiaeAnalysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresisHuman genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon responseA High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase InhibitorsInositol pyrophosphates: why so many phosphates?Conformational stability of inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) dictates its substrate selectivity.Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe.The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment.Identification of a functional nuclear translocation sequence in hPPIP5K2.Inositol Polyphosphate Binding Specificity of the Jasmonate Receptor Complex.Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.Synthetic tools for studying the chemical biology of InsP8.Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair.Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice.Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPs.PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains.Inositol pyrophosphates: between signalling and metabolism.TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.The Significance of the Bifunctional Kinase/Phosphatase Activities of Diphosphoinositol Pentakisphosphate Kinases (PPIP5Ks) for Coupling Inositol Pyrophosphate Cell Signaling to Cellular Phosphate Homeostasis.Towards pharmacological intervention in inositol pyrophosphate signalling.Chemical tools for interrogating inositol pyrophosphate structure and function.Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate SignallingIntimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.Cellular Cations Control Conformational Switching of Inositol Pyrophosphate Analogues.Adipocyte-specific deletion of Ip6k1 reduces diet-induced obesity by enhancing AMPK-mediated thermogenesis.Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae.Synthesis of unsymmetric diphospho-inositol polyphosphates.PPIP5K1 Suppresses Etoposide-triggered Apoptosis.
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P2860
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
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2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@ast
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@en
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
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type
label
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@ast
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@en
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@nl
prefLabel
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@ast
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@en
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@nl
P2860
P921
P3181
P356
P1476
Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
@en
P2093
Huanchen Wang
Stephen B Shears
P2860
P2888
P304
P3181
P356
10.1038/NCHEMBIO.733
P577
2011-11-27T00:00:00Z
P5875
P6179
1038790391