Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation - Wikidata - wikimedia - TriplyDB

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

http://www.wikidata.org/entity/Q27675893

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Integrin cytoplasmic tail interactions Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide Structural Determinants for Binding of Sorting Nexin 17 (SNX17) to the Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1)Cerebral Cavernous Malformations: Review of the Genetic and Protein-Protein Interactions Resulting in Disease Pathogenesis Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling Talins and kindlins: partners in integrin-mediated adhesion.Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis.The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.Regulation of integrin-mediated adhesions.Role of Krev Interaction Trapped-1 in Prostacyclin-Induced Protection against Lung Vascular Permeability Induced by Excessive Mechanical Forces and Thrombin Receptor Activating Peptide 6.Introduction to cerebral cavernous malformation: a brief review.Cerebral cavernous malformation proteins at a glance.αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.Mechanisms of talin-dependent integrin signaling and crosstalk Distinct functions for Rap1 signaling in vascular morphogenesis and dysfunction.CCM1 and the second life of proteins in adhesion complexes.Role of integrin alpha4 in drug resistance of leukemia Modulation of cytoskeletal dynamics by mammalian nucleoside diphosphate kinase (NDPK) proteins PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations.Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.The cerebral cavernous malformations proteins.CCM proteins control endothelial β1 integrin dependent response to shear stress.Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 (ICAP-1α) negatively regulates β1 integrins.Understanding the bone marrow microenvironment in hematologic malignancies: A focus on chemokine, integrin, and extracellular vesicle signaling.KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease.Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus.

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

http://www.wikidata.org/entity/Q27675893

description

2013 nî lūn-bûn

@nan

2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի փետրվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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type

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

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J.MOLCEL.2012.12.005

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Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation

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Kyle M Draheim

http://www.w3.org/2001/XMLSchema#string

Rong Zhang

http://www.w3.org/2001/XMLSchema#string

Titus J Boggon

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Weizhi Liu

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P2860

Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.

Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1

ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin

Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha

Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis

KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein.

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling

Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21

A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells

Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects

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719-729

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10.1016/J.MOLCEL.2012.12.005

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4

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49

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David A Calderwood

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