PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis - Wikidata - wikimedia - TriplyDB

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

http://www.wikidata.org/entity/Q27675952

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Computational approaches for inferring the functions of intrinsically disordered proteins Photoreceptor cell death and rescue in retinal detachment and degenerations Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators Exosomes in mesenchymal stem cells, a new therapeutic strategy for cardiovascular diseases?Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins The DNA-binding domain mediates both nuclear and cytosolic functions of p53 Bh3 induced conformational changes in Bcl-Xl revealed by crystal structure and comparative analysis TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL Evidence of conformational selection driving the formation of ligand binding sites in protein-protein interfaces Cancer/Testis Antigens: "Smart" Biomarkers for Diagnosis and Prognosis of Prostate and Other Cancers The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.Conditionally and transiently disordered proteins: awakening cryptic disorder to regulate protein function.B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles.Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.Allosteric inhibition of antiapoptotic MCL-1.Dynamics of the BH3-Only Protein Binding Interface of Bcl-xL.Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-X(L)/p53-mediated amplification mechanisms.From sequence and forces to structure, function, and evolution of intrinsically disordered proteins Regulated unfolding of proteins in signaling Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice Development of a lytic peptide derived from BH3-only proteins Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3 Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma Structural biology of the Bcl-2 family and its mimicry by viral proteins Evaluation of the BH3-only protein Puma as a direct Bak activator Bcl-2 proteins bid and bax form a network to permeabilize the mitochondria at the onset of apoptosis.Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity Many players in BCL-2 family affairs.Sphingolipids and mitochondrial apoptosis.Discoveries and controversies in BCL-2 protein-mediated apoptosis.The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.β-Ecdysterone Protects SH-SY5Y Cells Against 6-Hydroxydopamine-Induced Apoptosis via Mitochondria-Dependent Mechanism: Involvement of p38(MAPK)-p53 Signaling Pathway.Hypothesis: The unfolding power of protein dielectricity.The principle of conformational signaling.Physiological and Pharmacological Control of BAK, BAX, and Beyond.Combined gene expression and proteomic analysis of EGF induced apoptosis in A431 cells suggests multiple pathways trigger apoptosis.PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage Nerve growth factor reduces apoptotic cell death in rat facial motor neurons after facial nerve injury.Protein-protein interactions: A PUMA mechanism unfolds.

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P2860

PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis

http://www.wikidata.org/entity/Q27675952

description

2013 nî lūn-bûn

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2013 թուականի Մարտին հրատարակուած գիտական յօդուած

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2013 թվականի մարտին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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PUMA binding induces partial u ...... binding and promote apoptosis

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PUMA binding induces partial u ...... binding and promote apoptosis

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PUMA binding induces partial u ...... binding and promote apoptosis

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type

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PUMA binding induces partial u ...... binding and promote apoptosis

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PUMA binding induces partial u ...... binding and promote apoptosis

@en

PUMA binding induces partial u ...... binding and promote apoptosis

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prefLabel

PUMA binding induces partial u ...... binding and promote apoptosis

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PUMA binding induces partial u ...... binding and promote apoptosis

@en

PUMA binding induces partial u ...... binding and promote apoptosis

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Nature Chemical Biology

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PUMA binding induces partial u ...... binding and promote apoptosis

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Amanda Nourse

http://www.w3.org/2001/XMLSchema#string

Ariele Viacava Follis

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Christy R Grace

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John C Fisher

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Katherine Baran

http://www.w3.org/2001/XMLSchema#string

Li Ou

http://www.w3.org/2001/XMLSchema#string

Lie Min

http://www.w3.org/2001/XMLSchema#string

Mi-Kyung Yun

http://www.w3.org/2001/XMLSchema#string

Richard W Kriwacki

http://www.w3.org/2001/XMLSchema#string

Stephen W White

http://www.w3.org/2001/XMLSchema#string

P2860

PUMA induces the rapid apoptosis of colorectal cancer cells

PUMA, a novel proapoptotic gene, is induced by p53

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

PUMA couples the nuclear and cytoplasmic proapoptotic function of p53

PHENIX: a comprehensive Python-based system for macromolecular structure solution

The SWISS-MODEL Repository and associated resources

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

Processing of X-ray diffraction data collected in oscillation mode

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

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163-8

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4850175

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10.1038/NCHEMBIO.1166

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3

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9

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Douglas R. Green

Jerry E. Chipuk

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2013-03-01T00:00:00Z

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1025598620

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23340338

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apoptotic process

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3683295

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