Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor - Wikidata - wikimedia - TriplyDB

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

http://www.wikidata.org/entity/Q27676058

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Targeting Protein-Protein Interactions in the HIF System On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation Access Path to the Ligand Binding Pocket May Play a Role in Xenobiotics Selection by AhR Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization.Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.Current and future trends in the anatomical and functional imaging of head and neck paragangliomas.Hypoxia-inducible factor signaling in pheochromocytoma: turning the rudder in the right direction.Differential suppression of the aryl hydrocarbon receptor nuclear translocator-dependent function by an aryl hydrocarbon receptor PAS-A-derived inhibitory molecule.Targeting renal cell carcinoma with a HIF-2 antagonist.Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.Pheochromocytoma: Gasping for Air.Structural characterization of mammalian bHLH-PAS transcription factors.Macrophage-mediated response to hypoxia in disease.The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.Hypoxia inducible factor (HIF) as a model for studying inhibition of protein-protein interactions.The therapeutic potential of HIF-2 antagonism in renal cell carcinoma.William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award.Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α.Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.Molecular dynamics investigation of stereoselective inhibition mechanism of HIF-2α/ARNT heterodimer.Targeting HIF2 in Clear Cell Renal Cell Carcinoma.Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling.A new paradigm for GERD pathogenesis. Not acid injury, but cytokine-mediated inflammation driven by HIF-2α: a potential role for targeting HIF-2α to prevent and treat reflux esophagitis.Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics.

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P2860

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

http://www.wikidata.org/entity/Q27676058

description

2013 nî lūn-bûn

@nan

2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@ast

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@en

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@nl

type

label

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@ast

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@en

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@nl

prefLabel

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@ast

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@en

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@nl

P1433

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P1433

Journal of Medicinal Chemistry

P1476

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

@en

P2093

Cameron Shokri

http://www.w3.org/2001/XMLSchema#string

Doug E Frantz

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Jacinth Naidoo

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Jamie L Rogers

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Jamie Longgood

http://www.w3.org/2001/XMLSchema#string

Jason Key

http://www.w3.org/2001/XMLSchema#string

John B MacMillan

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Kevin H Gardner

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Liela Bayeh

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Lisa Melito

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P2860

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Hypoxia-inducible factors and the response to hypoxic stress

Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor

N- and C-terminal flanking regions modulate light-induced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from Avena sativa

Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor

Principles of Ligand Binding within a Completely Buried Cavity in HIF2α PAS-B

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

Targeting HIF-1 for cancer therapy

Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression

Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma

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1739-47

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scholarly article

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841175

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10.1021/JM301847Z

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4

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56

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2013-02-28T00:00:00Z

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23363003

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3676484

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