The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator - Wikidata - wikimedia - TriplyDB

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

http://www.wikidata.org/entity/Q27676681

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Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1 Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1 Double strand break repair functions of histone H2AX BCL10 regulates RNF8/RNF168-mediated ubiquitination in the DNA damage response.Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways.Dimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation Integrative proteomic and transcriptomic analyses reveal multiple post-transcriptional regulatory mechanisms of mouse spermatogenesis.Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks.DNA damage sensing by the ATM and ATR kinases.DNA Damage Response-Independent Role for MDC1 in Maintaining Genomic Stability DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss.The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair.Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains.Ring finger protein 126 (RNF126) suppresses ionizing radiation-induced p53-binding protein 1 (53BP1) focus formation.Live Cell Imaging to Study Real-Time ATM-Mediated Recruitment of DNA Repair Complexes to Sites of Ionizing Radiation-Induced DNA Damage.Hsp90α regulates ATM and NBN functions in sensing and repair of DNA double-strand breaks.

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The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator

http://www.wikidata.org/entity/Q27676681

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2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի մայիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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type

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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Nucleic Acids Research

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The molecular basis of ATM-dep ...... DNA damage checkpoint mediator

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Christoph Spycher

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Derek MacMillan

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Flurina J Hari

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Janette Lloyd

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Jiejin Li

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Julie A Clapperton

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Lesley F Haire

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Lucijana Pavic

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Manuel Stucki

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Mario Bonalli

http://www.w3.org/2001/XMLSchema#string

P2860

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

MDC1 is a mediator of the mammalian DNA damage checkpoint

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

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3913-28

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scholarly article

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10.1093/NAR/GKR1300

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9

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40

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Michael Lund Nielsen

Dorthe H Larsen

Stephen J Smerdon

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2012-05-01T00:00:00Z

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221738217

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22234878

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3351161

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