Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences - Wikidata - wikimedia - TriplyDB

Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

http://www.wikidata.org/entity/Q27676826

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Correcting the cystic fibrosis disease mutant, A455E CFTR Mechanisms of CFTR Folding at the Endoplasmic Reticulum New and emerging targeted therapies for cystic fibrosis Pharmacological chaperoning: a primer on mechanism and pharmacology Modulation of the maladaptive stress response to manage diseases of protein folding CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis ABCG2: the molecular mechanisms of urate secretion and gout Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTR Rescue of NBD2 mutants N1303K and S1235R of CFTR by small-molecule correctors and transcomplementation Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.Stabilization of Nucleotide Binding Domain Dimers Rescues ABCC6 Mutants Associated with Pseudoxanthoma Elasticum.Development of CFTR Structure Enhancing the Potency of F508del Correction: A Multi-Layer Combinational Approach to Drug Discovery for Cystic Fibrosis.Alteration of protein function by a silent polymorphism linked to tRNA abundance.Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.Complement yourself: Transcomplementation rescues partially folded mutant proteins.Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor Decoding F508del misfolding in cystic fibrosis.A chaperone trap contributes to the onset of cystic fibrosis.VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA Pharmacological Correctors of Mutant CFTR Mistrafficking.Targeted proteomic quantitation of the absolute expression and turnover of cystic fibrosis transmembrane conductance regulator in the apical plasma membrane.Rescue of murine F508del CFTR activity in native intestine by low temperature and proteasome inhibitors Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation.Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.Rescuing Trafficking Mutants of the ATP-binding Cassette Protein, ABCA4, with Small Molecule Correctors as a Treatment for Stargardt Eye Disease.Pharmacogenomics: mapping monogenic mutations to direct therapy Pharmacological rescue of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) detected by use of a novel fluorescence platform Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activity Molecular modelling and molecular dynamics of CFTR.Cystic fibrosis lung environment and Pseudomonas aeruginosa infection.Hallmarks of therapeutic management of the cystic fibrosis functional landscape.Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization.Combination of Correctors Rescue ΔF508-CFTR by Reducing Its Association with Hsp40 and Hsp27.Capturing the Direct Binding of CFTR Correctors to CFTR by Using Click Chemistry.

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Requirements for Efficient Correction of ΔF508 CFTR Revealed by Analyses of Evolved Sequences

http://www.wikidata.org/entity/Q27676826

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2012 nî lūn-bûn

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2012 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2012年の論文

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2012年論文

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2012年论文

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Requirements for Efficient Cor ...... Analyses of Evolved Sequences

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Requirements for Efficient Cor ...... Analyses of Evolved Sequences

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Requirements for Efficient Cor ...... Analyses of Evolved Sequences

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Andrew P Feranchak

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André Schmidt

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Emmanuel Nuvaga

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Tyler Barrett

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold

Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP

Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry

Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant

Clustal W and Clustal X version 2.0

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1-2

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Chad A Brautigam

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2012-01-20T00:00:00Z

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