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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

http://www.wikidata.org/entity/Q27677345

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Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells Wnt/beta-catenin signaling and small molecule inhibitors Trial watch - inhibiting PARP enzymes for anticancer therapy Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine Recent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterization PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier.Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review Crystal Structure of Human ADP-ribose Transferase ARTD15/PARP16 Reveals a Novel Putative Regulatory Domain Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3- b ]pyridazin-8-amine Derivatives as Tankyrase Inhibitors Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors Discovery and Structure–Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-carboxamide and 2,3-Dihydrobenzofuran-3(2 H )-one-7-carboxamide Derivatives as Poly(ADP-ribose)polymerase-1 Inhibitors para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors Understanding specific functions of PARP-2: new lessons for cancer therapy Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment ADP-ribosyltransferases and poly ADP-ribosylation ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.Probing the activity modification space of the cysteine peptidase cathepsin K with novel allosteric modifiers Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation HemI: a toolkit for illustrating heatmaps Conversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase Activity Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.No Silver Bullet - Canonical Poly(ADP-Ribose) Polymerases (PARPs) Are No Universal Factors of Abiotic and Biotic Stress Resistance of Arabidopsis thaliana.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer.Synthesis, [¹⁸F] radiolabeling, and evaluation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors for in vivo imaging of PARP-1 using positron emission tomography.DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells Computational repositioning and preclinical validation of pentamidine for renal cell cancer.Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression.PARP inhibition delays progression of mitochondrial encephalopathy in mice.Family-wide analysis of poly(ADP-ribose) polymerase activity Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition A role of intracellular mono-ADP-ribosylation in cancer biology.Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines.Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.Development of synthetic lethality anticancer therapeutics.RNA-seq profiling of a radiation resistant and radiation sensitive prostate cancer cell line highlights opposing regulation of DNA repair and targets for radiosensitization.

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

http://www.wikidata.org/entity/Q27677345

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012 թվականի փետրվարին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Nature Biotechnology

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Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors

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Antonio Macchiarulo

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Delal Öncü

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Ekaterina Kouznetsova

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Ewa Pol

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Graeme Michael Robertson

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Natalia Markova

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Roberto Pellicciari

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Torun Ekblad

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Åsa Frostell

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P2860

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Zinc binding catalytic domain of human tankyrase 1

Novel inhibitors of poly(ADP-ribose) synthetase

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs)

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor

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283-8

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3322033

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10.1038/NBT.2121

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3

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30

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Herwig Schüler

Ann-Gerd Thorsell

Tobias Karlberg

Elisabet Wahlberg

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2012-02-19T00:00:00Z

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221841442

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1017766920

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22343925

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