Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum
about
Structural studies on Mycobacterium tuberculosis DXR in complex with the antibiotic FR-900098Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate ReductoisomeraseTargeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of FosmidomycinNew Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in PlasmodiumA systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplastKinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)Enzyme inhibitor studies reveal complex control of methyl-D-erythritol 4-phosphate (MEP) pathway enzyme expression in Catharanthus roseusStructure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor.An integrative analysis of small molecule transcriptional responses in the human malaria parasite Plasmodium falciparumFR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicityMechanistic aspects of carotenoid biosynthesis.Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum.From crystal to compound: structure-based antimalarial drug discovery.MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria.A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi.Synthetic Fosmidomycin analogues with altered chelating moieties do not inhibit 1-deoxy-d-xylulose 5-phosphate Reductoisomerase or Plasmodium falciparum growth in vitro.Inverse docking based screening and identification of protein targets for Cassiarin alkaloids against Plasmodium falciparum.
P2860
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P2860
Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum
description
2011 nî lūn-bûn
@nan
2011 թուականին հրատարակուած գիտական յօդուած
@hyw
2011 թվականին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@ast
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@en
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@nl
type
label
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@ast
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@en
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@nl
prefLabel
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@ast
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@en
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@nl
P2093
P2860
P3181
P356
P1433
P1476
Molecular basis of fosmidomyci ...... parasite Plasmodium falciparum
@en
P2093
Kazuo T Nakamura
Masayuki Nakanishi
Nobutada Tanaka
Tomonobu Umeda
Yoshio Kusakabe
Yukio Kitade
P2860
P2888
P3181
P356
10.1038/SREP00009
P407
P577
2011-01-01T00:00:00Z
P5875
P6179
1017123835