Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization
about
Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding SiteStructure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodiesBinding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study.CD4 mimetics sensitize HIV-1-infected cells to ADCC.Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.Computational Evaluation of HIV-1 gp120 Conformations of Soluble Trimeric gp140 Structures as Targets for de Novo Docking of First- and Second-Generation Small-Molecule CD4 Mimics.Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds.Driving HIV-1 into a Vulnerable Corner by Taking Advantage of Viral Adaptation and Evolution.Design, synthesis and evaluation of small molecule CD4-mimics as entry inhibitors possessing broad spectrum anti-HIV-1 activity.Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells.2-Aminothiazolones as anti-HIV agents that act as gp120-CD4 inhibitors.Computational identification of novel entry inhibitor scaffolds mimicking primary receptor CD4 of HIV-1 gp120.Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors.Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions.Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region.Specific Non-Covalent Interactions Determine Optimal Structure of a Buried Ligand Moiety: QM/MM and Pure QM Modeling of Complexes of the Small-Molecule CD4 Mimetics and HIV1 Gp120.
P2860
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P2860
Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structure-Based Design and Syn ...... Thermodynamic Characterization
@ast
Structure-Based Design and Syn ...... Thermodynamic Characterization
@en
Structure-Based Design and Syn ...... Thermodynamic Characterization
@nl
type
label
Structure-Based Design and Syn ...... Thermodynamic Characterization
@ast
Structure-Based Design and Syn ...... Thermodynamic Characterization
@en
Structure-Based Design and Syn ...... Thermodynamic Characterization
@nl
prefLabel
Structure-Based Design and Syn ...... Thermodynamic Characterization
@ast
Structure-Based Design and Syn ...... Thermodynamic Characterization
@en
Structure-Based Design and Syn ...... Thermodynamic Characterization
@nl
P2093
P2860
P356
P1476
Structure-Based Design and Syn ...... Thermodynamic Characterization
@en
P2093
Amos B Smith
Amy M Princiotto
Arne Schön
David M Jones
Ernesto Freire
Joel R Courter
Jongwoo Park
Judith M Lalonde
Matthew Le-Khac
Navid Madani
P2860
P304
P356
10.1021/ML300407Y
P577
2013-03-01T00:00:00Z