Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain
about
Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancyStructural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibitedSteric Mechanism of Auto-Inhibitory Regulation of Specific and Non-Specific DNA Binding by the ETS Transcriptional Repressor ETV6Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.Allosteric Autoinhibition Pathway in Transcription Factor ERG: Dynamics Network and Mutant Experimental Evaluations.Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors.Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.Recalculation of 23 mouse HDL QTL datasets improves accuracy and allows for better candidate gene analysis.Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.The oncogene ERG: a key factor in prostate cancer.Autoinhibitory mechanisms of ERG studied by molecular dynamics simulations.Conformational Dynamics and the Binding of Specific and Nonspecific DNA by the Autoinhibited Transcription Factor Ets-1Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix.Signatures of DNA target selectivity by ETS transcription factors.Electrostatic control of DNA intersegmental translocation by the ETS transcription factor ETV6.
P2860
Q24314163-8EE0D9A1-14D1-4EE5-8F64-5F393241CC04Q27679276-0DCAAA16-840B-42CB-9AF3-05ED4E777211Q27680868-F2BEA4FD-0274-42AE-B384-003F9A2AF486Q30373611-7CB39F36-E097-4157-AF7C-73E433B78B0DQ30401225-FB9EB1FF-C1D1-4A21-A32C-105BC0BD1439Q33435561-EF976083-C734-40E7-98E4-B4D46051D720Q33558203-7FB538E9-6CA8-44B1-BE78-46840AC80A78Q36709654-C6F41FB6-7401-4D37-8A26-A929A138D9DCQ38180770-69EA86EF-67CC-4D60-9A96-B08EB25DF546Q38444138-D85D0437-2D87-4A9C-8A7D-1F29A2D4E3A9Q39315480-4642EEB2-6545-4705-B1D1-CDED386BACFDQ39642594-B71A9CED-90BA-4D68-8E1A-6147A194BB4DQ41555169-D942819D-7800-4382-B02F-5EF929E2C6F5Q48115869-3182C6D3-0F72-4F75-9BB7-288B0691EE52Q48311413-4853F0D3-C536-4815-96F2-2A9F6FF7B563
P2860
Autoinhibition of ETV6 (TEL) DNA Binding: Appended Helices Sterically Block the ETS Domain
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2012 nî lūn-bûn
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2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@ast
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@en
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@nl
type
label
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@ast
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@en
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@nl
prefLabel
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@ast
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@en
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@nl
P2093
P2860
P1476
Autoinhibition of ETV6 (TEL) D ...... terically Block the ETS Domain
@en
P2093
Barbara J Graves
H Jerome Coyne
Lawrence P McIntosh
Niraja Bhachech
Sean M Green
P2860
P356
10.1016/J.JMB.2012.05.010
P407
P577
2012-08-03T00:00:00Z