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Structure and function of CarD, an essential mycobacterial transcription factor

Structure and function of CarD, an essential mycobacterial transcription factor

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The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis Crystal structure of Mycobacterium tuberculosis CarD, an essential RNA polymerase binding protein, reveals a quasidomain-swapped dimeric structural architecture Bacterial RNA Polymerase-DNA Interaction-The Driving Force of Gene Expression and the Target for Drug Action Mycobacterium tuberculosis Transcription Machinery: Ready To Respond to Host Attacks Drug Repurposing: Tolfenamic Acid Inactivates PrbP, a Transcriptional Accessory Protein in Liberibacter asiaticus Genome-Wide Mapping of the Distribution of CarD, RNAP σ(A), and RNAP β on the Mycobacterium smegmatis Chromosome using Chromatin Immunoprecipitation Sequencing.CarD integrates three functional modules to promote efficient transcription, antibiotic tolerance, and pathogenesis in mycobacteria.The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase.CarD stabilizes mycobacterial open complexes via a two-tiered kinetic mechanism Structural insights into RNA polymerase recognition and essential function of Myxococcus xanthus CdnL Structure-function dissection of Myxococcus xanthus CarD N-terminal domain, a defining member of the CarD_CdnL_TRCF family of RNA polymerase interacting proteins.Ubiquitous promoter-localization of essential virulence regulators in Francisella tularensis Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA Identification of CdnL, a Putative Transcriptional Regulator Involved in Repair and Outgrowth of Heat-Damaged Bacillus cereus Spores Transcriptomic analysis of the stationary phase response regulator SpdR in Caulobacter crescentus.CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex.The bacterial cell cycle regulator GcrA is a σ70 cofactor that drives gene expression from a subset of methylated promoters.Cooperative stabilization of Mycobacterium tuberculosis rrnAP3 promoter open complexes by RbpA and CarD.Structure of the carboxy-terminal domain of Mycobacterium tuberculosis CarD protein: an essential rRNA transcriptional regulator Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA.Caulobacter crescentus CdnL is a non-essential RNA polymerase-binding protein whose depletion impairs normal growth and rRNA transcription.Characterization of a minimal type of promoter containing the -10 element and a guanine at the -14 or -13 position in mycobacteria.Local and global regulation of transcription initiation in bacteria.The physiology of growth arrest: uniting molecular and environmental microbiology.Identification of the Tolfenamic Acid Binding Pocket in PrbP from Liberibacter asiaticus.Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence.Early diagnosis and effective treatment regimens are the keys to tackle antimicrobial resistance in tuberculosis (TB): A report from Euroscicon's international TB Summit 2016.Bacterial Survival under Extreme UV Radiation: A Comparative Proteomics Study of Rhodobacter sp., Isolated from High Altitude Wetlands in Chile Mycobacterium RbpA cooperates with the stress-response σB subunit of RNA polymerase in promoter DNA unwinding.Mycobacterial RNA polymerase forms unstable open promoter complexes that are stabilized by CarD.Two zinc finger proteins from Mycobacterium smegmatis: DNA binding and activation of transcription.RbpA relaxes promoter selectivity of M. tuberculosis RNA polymerase

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Structure and function of CarD, an essential mycobacterial transcription factor

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2013 nî lūn-bûn

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2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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Structure and function of CarD, an essential mycobacterial transcription factor

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Structure and function of CarD, an essential mycobacterial transcription factor

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Structure and function of CarD, an essential mycobacterial transcription factor

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Structure and function of CarD, an essential mycobacterial transcription factor

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Structure and function of CarD, an essential mycobacterial transcription factor

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Christina L Stallings

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Joseph Osmundson

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Seth A Darst

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P2860

Electrostatics of nanosystems: application to microtubules and the ribosome

Regulator trafficking on bacterial transcription units in vivo

Structure of the bacterial RNA polymerase promoter specificity sigma subunit

Structural basis of transcription initiation: an RNA polymerase holoenzyme-DNA complex

Structural basis of transcription activation: the CAP-alpha CTD-DNA complex

Structure of a ternary transcription activation complex

Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction

Structural Basis for Promoter −10 Element Recognition by the Bacterial RNA Polymerase σ Subunit

NMR structure note: N-terminal domain of Thermus thermophilus CdnL

Preparation of selenomethionyl proteins for phase determination

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